A PE-PGRS33 protein of Mycobacterium tuberculosis: An ideal target for future tuberculosis vaccine design

Paola Gastelum-Aviña; Carlos Velazquez; Clara Espitia; Fernando Lares-Villa; Adriana Garibay-Escobar

doi:10.1586/14760584.2015.1015995

A PE-PGRS33 protein of Mycobacterium tuberculosis: An ideal target for future tuberculosis vaccine design

Paola Gastelum-Aviña, Carlos Velazquez, Clara Espitia, Fernando Lares-Villa, Adriana Garibay-Escobar^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

It is known that cellular immune response is relevant to fight against tuberculosis (TB); hence, identification of mycobacterial antigens that induce a protective immune cellular response is of great interest, especially for the development of effective TB vaccines. Genomic data have an impact on the identification of potential antigens as new vaccine targets. In this review, we summarize the current knowledge about the advances in new TB vaccine designs as well as the features reported for the pro-glu-polymorphic GC-rich sequence (PE-PGRS33) protein, considering this molecule as a prototype of the PE-PGRS family to better understand the biological function of this protein family that could be considered an ideal target for future vaccine design.

Original language	English
Pages (from-to)	699-711
Number of pages	13
Journal	Expert Review of Vaccines
Volume	14
Issue number	5
DOIs	https://doi.org/10.1586/14760584.2015.1015995
State	Published - 1 May 2015

Bibliographical note

Publisher Copyright:
© Informa UK, Ltd.

Keywords

BCG
PE-PGRS
PE-PGRS33
subunit vaccine
tuberculosis

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10.1586/14760584.2015.1015995

Cite this

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title = "A PE-PGRS33 protein of Mycobacterium tuberculosis: An ideal target for future tuberculosis vaccine design",

abstract = "It is known that cellular immune response is relevant to fight against tuberculosis (TB); hence, identification of mycobacterial antigens that induce a protective immune cellular response is of great interest, especially for the development of effective TB vaccines. Genomic data have an impact on the identification of potential antigens as new vaccine targets. In this review, we summarize the current knowledge about the advances in new TB vaccine designs as well as the features reported for the pro-glu-polymorphic GC-rich sequence (PE-PGRS33) protein, considering this molecule as a prototype of the PE-PGRS family to better understand the biological function of this protein family that could be considered an ideal target for future vaccine design.",

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AU - Espitia, Clara

AU - Lares-Villa, Fernando

AU - Garibay-Escobar, Adriana

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A PE-PGRS33 protein of Mycobacterium tuberculosis: An ideal target for future tuberculosis vaccine design

Abstract

Bibliographical note

Keywords

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