TY - JOUR
T1 - A PE-PGRS33 protein of Mycobacterium tuberculosis: An ideal target for future tuberculosis vaccine design
AU - Gastelum-Aviña, Paola
AU - Velazquez, Carlos
AU - Espitia, Clara
AU - Lares-Villa, Fernando
AU - Garibay-Escobar, Adriana
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © Informa UK, Ltd. It is known that cellular immune response is relevant to fight against tuberculosis (TB); hence, identification of mycobacterial antigens that induce a protective immune cellular response is of great interest, especially for the development of effective TB vaccines. Genomic data have an impact on the identification of potential antigens as new vaccine targets. In this review, we summarize the current knowledge about the advances in new TB vaccine designs as well as the features reported for the pro-glu-polymorphic GC-rich sequence (PE-PGRS33) protein, considering this molecule as a prototype of the PE-PGRS family to better understand the biological function of this protein family that could be considered an ideal target for future vaccine design.
AB - © Informa UK, Ltd. It is known that cellular immune response is relevant to fight against tuberculosis (TB); hence, identification of mycobacterial antigens that induce a protective immune cellular response is of great interest, especially for the development of effective TB vaccines. Genomic data have an impact on the identification of potential antigens as new vaccine targets. In this review, we summarize the current knowledge about the advances in new TB vaccine designs as well as the features reported for the pro-glu-polymorphic GC-rich sequence (PE-PGRS33) protein, considering this molecule as a prototype of the PE-PGRS family to better understand the biological function of this protein family that could be considered an ideal target for future vaccine design.
U2 - 10.1586/14760584.2015.1015995
DO - 10.1586/14760584.2015.1015995
M3 - Scientific review
SN - 1476-0584
SP - 699
EP - 711
JO - Expert Review of Vaccines
JF - Expert Review of Vaccines
ER -