A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile

L. A. Bautista-Herrera, U. De la Cruz-Mosso, I. V. Román-Fernández, I. Parra-Rojas, J. G. Soñanez-Organis, J. Hernández-Bello, R. A. Morales-Zambrano, G. D. Villanueva-Quintero, J. F. Muñoz-Valle

Research output: Contribution to journalArticle

Abstract

The goals of our study were to determine the possible association of interleukin (IL)-31 with Th17 cytokine profile in serum and to quantify retinoic acid-related orphan receptor C (RORC) mRNA expression in psoriatic arthritis (PsA) patients. This cross-sectional study was conducted in 50 patients with PsA and 30 control subjects (CS) matched by age and gender. The cytokine serum levels were quantified by magnetic bead-based assay using the Bio-Plex MAGPIX system, and RORC mRNA expression was determined by quantitative polymerase chain reaction (qPCR). As a result, significant differences in IL-31 were observed between study groups (77.23 pg/mL in PsA vs 64.4 pg/mL in CS, P 
Original languageAmerican English
JournalInternational journal of immunopathology and pharmacology
Volume34
DOIs
StatePublished - 1 Jan 2020

Keywords

  • IL-31
  • RORC
  • Th17 cytokine profile
  • mRNA expression
  • psoriatic arthritis

Cite this

Bautista-Herrera, L. A., De la Cruz-Mosso, U., Román-Fernández, I. V., Parra-Rojas, I., Soñanez-Organis, J. G., Hernández-Bello, J., Morales-Zambrano, R. A., Villanueva-Quintero, G. D., & Muñoz-Valle, J. F. (2020). A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile. International journal of immunopathology and pharmacology, 34. https://doi.org/10.1177/2058738420907186