Acute inflammatory mediators in young adult patients with covid-19 in Mexico

Anahí Maldonado-Cabrera, Aracely Angulo-Molina*, Ubydul Haque, Carlos Velazquez, Andrea S. Álvarez-Villaseñor, Karla J. Santacruz-Gómez, Ana L. Gallego-Hernández*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Young adults (18–40 years old) are an active population with high risk of infection and transmission of COVID-19. They are considered a low-risk population due to its low 1.0% case fatality rate (CFR). Despite their high clinical usefulness to prevent fatal cases, inflammatory and coagulation biomarkers studies are limited. For this reason, we performed a retrospective cohort study with COVID-19 patients in Hermosillo, Mexico, to assess inflammation, coagulopathy profile, and severity outcomes in young adults. We analyzed blood samples to determine the neutrophil/lymphocyte ratio (NLR), neutrophil/monocyte ratio (NMR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), and C-reactive protein (C-RP). We included epidemiological features and comorbidities, and compared them to the severity status. Only 359 COVID-19-confirmed young adults were included in the ambulatory (44.8%), hospitalized (42.9%), and death (12%) severity groups. Laboratory results showed an increase in NMR, LMR, and C-RP associated with the aggravated patients. Additionally, obesity, arterial hypertension, and type-2 diabetes mellitus (T2DM) were associated with the COVID-19 severity outcome. We found that 9.1% and 30.3% of young adults presented the novel COVID-19-associated coagulopathy (CAC) and the risk of CAC, respectively. These parameters can be considered independent biomarkers reflecting an enhanced inflammatory process related to the COVID-19 prognosis.

Original languageEnglish
Article number1056
Issue number8
StatePublished - Aug 2021

Bibliographical note

Funding Information:
Funding: We acknowledge the Department of Chemical-Biological Science, the Division of Biological and Health Science, and the Division of Exact and Natural Science of the University of Sonora for their financial support to cover the publication fees of this article. UH was supported by the Research Council of Norway (Grant # 281077).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • COVID-19
  • Coagulopathy
  • Hematological profiles
  • Young adults


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