Adenine nucleotide recognition by spiramycin and some of its aromatic derivatives

Karla Isabel Rivera-Márquez, Carolina Godoy-Alcántar, Miguel Ángel Claudio-Catalán, Felipe Medrano

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

© 2016, Springer Science+Business Media Dordrecht. Association of adenine nucleotides with the macrocyclic antibiotic Spiramycin and two of its aromatic derivatives was studied by potentiometric titrations, 1H and 31P NMR spectrometry and molecular modelling. Spiramycin binds adenine nucleotides with K ≈ 103–104 M−1 and selectivity for ADP over ATP or AMP. The introduction of aromatic moieties reduces the strength of the binding but, selectivity order changes to ATP > ADP > AMP. Molecular models showed that complexes are mainly stabilized by electrostatic interactions between the protonated amino groups of the receptors and the phosphate groups of the nucleotides.
Original languageAmerican English
Pages (from-to)211-219
Number of pages9
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
DOIs
StatePublished - 1 Dec 2016
Externally publishedYes

Fingerprint

Dive into the research topics of 'Adenine nucleotide recognition by spiramycin and some of its aromatic derivatives'. Together they form a unique fingerprint.

Cite this