An updated overview on the resistance and virulence of UPEC

Edwin Barrios-Villa, Luciana Robino Picón, Rodolfo Bernal Reynaga, Margarita María de la Paz Arenas-Hernández*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Among infections related to ExPEC pathogens, UTIs caused by UPEC are the most prevalent in children and adults worldwide. The latter pathogenic strains exhibit an extensive set of virulence factors such as adhesins, iron uptake systems, and toxins that provide them with the ability to colonize and invade the urinary tract causing different pathologies. Besides these properties, UPEC strains have been reported to possess multidrug resistance to commonly used antibiotics such as β-lactams, fluoroquinolones, carbapenems, and cephalosporins, which complicate the treatment and demonstrate the need of alternative strategies against these pathogens. Updated strategies include vaccines, plant extracts, probiotics, phage therapy, and others, but they need to be widely evaluated before applying them as a common form of therapy. Finally, it is important to note that epidemiological studies that can identify UPEC are necessary to find the most effective way to avoid spread and infection with resistant strains and combat them with novel, high-efficiency treatments.

Original languageEnglish
Title of host publicationTrending Topics in Escherichia coli Research
Subtitle of host publicationThe Latin American Perspective
PublisherSpringer International Publishing
Number of pages28
ISBN (Electronic)9783031298820
ISBN (Print)9783031298813
StatePublished - 28 Jun 2023

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.


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