TY - JOUR
T1 - Antibacterial activity of sonoran propolis and some of its constituents against clinically significant vibrio species
AU - Navarro-Navarro, Moises
AU - Ruiz-Bustos, Patricia
AU - Valencia, Dora
AU - Robles-Zepeda, Ramón
AU - Ruiz-Bustos, Eduardo
AU - Virués, Claudia
AU - Hernandez, Javier
AU - Domínguez, Zaira
AU - Velazquez, Carlos
PY - 2013/2/1
Y1 - 2013/2/1
N2 - The aim of the present study was to evaluate the anti-Vibrio activity of propolis collected from three different areas of the Sonoran Desert in northwestern, Mexico [Pueblo de Alamos (PAP), Ures (UP), and Caborca (CP)]. The anti-Vibrio spp. activity of Sonoran propolis was determined by the broth microdilution method. UP propolis showed the highest antibacterial activity [minimal inhibitory concentration (MIC50)<50 μg mL -1] against Vibrio spp. (UP>CP>PAP). UP propolis significantly inhibited the growth of Vibrio cholerae O1 serotype Inaba (MIC 50<50 μg mL-1), V. cholerae non-O1 (MIC 50<50 μg mL-1), V. vulnificus (MIC 50<50 μg mL-1), and V. cholerae O1 serotype Ogawa (MIC50 100 μg mL-1), in a concentration-dependent manner. The UP propolis constituents, galangin and caffeic acid phenethyl ester (CAPE), exhibited a potent growth inhibitory activity (MIC50 0.05-0.1 mmol l-1) against V. cholerae strains (non-O1 and serotype Ogawa). The strong anti-Vibrio activity of Sonoran propolis and some of its chemical constituents (galangin and CAPE) support further studies on the clinical applications of this natural bee product against different Vibrio spp., mainly V. cholerae.
AB - The aim of the present study was to evaluate the anti-Vibrio activity of propolis collected from three different areas of the Sonoran Desert in northwestern, Mexico [Pueblo de Alamos (PAP), Ures (UP), and Caborca (CP)]. The anti-Vibrio spp. activity of Sonoran propolis was determined by the broth microdilution method. UP propolis showed the highest antibacterial activity [minimal inhibitory concentration (MIC50)<50 μg mL -1] against Vibrio spp. (UP>CP>PAP). UP propolis significantly inhibited the growth of Vibrio cholerae O1 serotype Inaba (MIC 50<50 μg mL-1), V. cholerae non-O1 (MIC 50<50 μg mL-1), V. vulnificus (MIC 50<50 μg mL-1), and V. cholerae O1 serotype Ogawa (MIC50 100 μg mL-1), in a concentration-dependent manner. The UP propolis constituents, galangin and caffeic acid phenethyl ester (CAPE), exhibited a potent growth inhibitory activity (MIC50 0.05-0.1 mmol l-1) against V. cholerae strains (non-O1 and serotype Ogawa). The strong anti-Vibrio activity of Sonoran propolis and some of its chemical constituents (galangin and CAPE) support further studies on the clinical applications of this natural bee product against different Vibrio spp., mainly V. cholerae.
UR - http://www.scopus.com/inward/record.url?scp=84879121563&partnerID=8YFLogxK
U2 - 10.1089/fpd.2012.1318
DO - 10.1089/fpd.2012.1318
M3 - Artículo
SN - 1535-3141
VL - 10
SP - 150
EP - 158
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
IS - 2
ER -