Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei)

Griselda Wilson-Sanchez, Carolina Moreno-Félix, Carlos Velazquez, Maribel Plascencia-Jatomea, Anita Acosta, Lorena Machi-Lara, María Lourdes Aldana-Madrid, Josafat Marina Ezquerra-Brauer, Ramón Robles-Zepeda, Armando Burgos-Hernandez

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18 Scopus citations

Abstract

An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B1, showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB1and proliferation of a cancer cell line. © 2010 by the authors.
Original languageAmerican English
Pages (from-to)2795-2809
Number of pages15
JournalMarine Drugs
DOIs
StatePublished - 1 Nov 2010

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