Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

Alex J. Salazar-Medina; Rocío Sugich-Miranda; Eli Teran-Cabanillas; Jesús Hernández; Gustavo A. González-Aguilar; Enrique Rudiño-Piñera; Rogerio R. Sotelo-Mundo; Enrique F. Velázquez-Contreras

doi:10.3390/molecules18021762

Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

Alex J. Salazar-Medina, Rocío Sugich-Miranda, Eli Teran-Cabanillas, Jesús Hernández, Gustavo A. González-Aguilar, Enrique Rudiño-Piñera, Rogerio R. Sotelo-Mundo, Enrique F. Velázquez-Contreras

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Abstract

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models. © 2013 by the authors.

Original language	American English
Pages (from-to)	1762-1774
Number of pages	13
Journal	Molecules
DOIs	https://doi.org/10.3390/molecules18021762
State	Published - 1 Feb 2013

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@article{3bd3f7a87b584845a874ec4e0655ead4,

title = "Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes",

abstract = "The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models. {\textcopyright} 2013 by the authors.",

author = "Salazar-Medina, {Alex J.} and Roc{\'i}o Sugich-Miranda and Eli Teran-Cabanillas and Jes{\'u}s Hern{\'a}ndez and Gonz{\'a}lez-Aguilar, {Gustavo A.} and Enrique Rudi{\~n}o-Pi{\~n}era and Sotelo-Mundo, {Rogerio R.} and Vel{\'a}zquez-Contreras, {Enrique F.}",

year = "2013",

month = feb,

day = "1",

doi = "10.3390/molecules18021762",

language = "American English",

pages = "1762--1774",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

AU - Salazar-Medina, Alex J.

AU - Sugich-Miranda, Rocío

AU - Teran-Cabanillas, Eli

AU - Hernández, Jesús

AU - González-Aguilar, Gustavo A.

AU - Rudiño-Piñera, Enrique

AU - Sotelo-Mundo, Rogerio R.

AU - Velázquez-Contreras, Enrique F.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models. © 2013 by the authors.

AB - The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models. © 2013 by the authors.

U2 - 10.3390/molecules18021762

DO - 10.3390/molecules18021762

M3 - Article

SP - 1762

EP - 1774

JO - Molecules

JF - Molecules

SN - 1420-3049

ER -

Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

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