Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

Alex J. Salazar-Medina, Rocío Sugich-Miranda, Eli Teran-Cabanillas, Jesús Hernández, Gustavo A. González-Aguilar, Enrique Rudiño-Piñera, Rogerio R. Sotelo-Mundo, Enrique F. Velázquez-Contreras

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models. © 2013 by the authors.
Original languageAmerican English
Pages (from-to)1762-1774
Number of pages13
JournalMolecules
DOIs
StatePublished - 1 Feb 2013

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