Betaine Aldehyde Dehydrogenase expression during physiological cardiac hypertrophy induced by pregnancy

Jesús Alfredo Rosas-Rodríguez, José Guadalupe Soñanez-Organis, José Arquimides Godoy-Lugo, Juan Alberto Espinoza-Salazar, Cesar Jeravy López-Jacobo, Norma Aurora Stephens-Camacho, Guadalupe González-Ochoa

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

© 2017 Elsevier Inc. Betaine Aldehyde Dehydrogenase (betaine aldehyde: NAD(P)+oxidoreductase, (E.C. 1.2.1.8; BADH) catalyze the irreversible oxidation of betaine aldehyde (BA) to glycine betaine (GB) and is essential for polyamine catabolism, γ-aminobutyric acid synthesis, and carnitine biosynthesis. GB is an important osmolyte that regulates the homocysteine levels, contributing to a vascular risk factor reduction. In this sense, distinct investigations describe the physiological roles of GB, but there is a lack of information about the GB novo synthesis process and regulation during cardiac hypertrophy induced by pregnancy. In this work, the BADH mRNA expression, protein level, and activity were quantified in the left ventricle before, during, and after pregnancy. The mRNA expression, protein content and enzyme activity along with GB content of BADH increased 2.41, 1.95 and 1.65-fold respectively during late pregnancy compared to not pregnancy, and returned to basal levels at postpartum. Besides, the GB levels increased 1.53-fold during pregnancy and remain at postpartum. Our results demonstrate that physiological cardiac hypertrophy induced BADH mRNA expression and activity along with GB production, suggesting that BADH participates in the adaptation process of physiological cardiac hypertrophy during pregnancy, according to the described GB role in cellular osmoregulation, osmoprotection and reduction of vascular risk.
Original languageAmerican English
Pages (from-to)623-628
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume490
Issue number3
DOIs
StatePublished - 26 Aug 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

  • Betaine aldehyde dehydrogenase
  • Glycine betaine
  • Physiological cardiac hypertrophy
  • Protein expression and left ventricle
  • mRNA

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