Bioactive lipidic extracts from octopus (paraoctopus limaculatus): Antimutagenicity and antiproliferative studies

Carolina Moreno-Félix, Griselda Wilson-Sánchez, Susana Gabriela Cruz-Ramírez, Carlos Velázquez-Contreras, Maribel Plascencia-Jatomea, Ana Acosta, Lorena MacHi-Lara, María Lourdes Aldana-Madrid, Josafat Marina Ezquerra-Brauer, Fernando Rocha-Alonzo, Armando Burgos-Hernández*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using thin layer chromatography (TLC), and each fraction was tested for antimutagenic and antiproliferative activities. Organic extract reduced the number of revertants caused by aflatoxin Bshowing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. Based on the results obtained, the isolated fractions obtained from octopus contain compounds with chemoprotective properties that reduce the mutagenicity of AFBand proliferation of cancer cell lines.

Original languageEnglish
Article number273582
JournalEvidence-based Complementary and Alternative Medicine
StatePublished - 2013


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