TY - JOUR
T1 - Bioactive lipidic extracts from octopus (paraoctopus limaculatus): Antimutagenicity and antiproliferative studies
AU - Moreno-Félix, Carolina
AU - Wilson-Sánchez, Griselda
AU - Cruz-Ramírez, Susana Gabriela
AU - Velázquez-Contreras, Carlos
AU - Plascencia-Jatomea, Maribel
AU - Acosta, Ana
AU - MacHi-Lara, Lorena
AU - Aldana-Madrid, María Lourdes
AU - Ezquerra-Brauer, Josafat Marina
AU - Rocha-Alonzo, Fernando
AU - Burgos-Hernández, Armando
PY - 2013/2/11
Y1 - 2013/2/11
N2 - Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using thin layer chromatography (TLC), and each fraction was tested for antimutagenic and antiproliferative activities. Organic extract reduced the number of revertants caused by aflatoxin Bshowing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. Based on the results obtained, the isolated fractions obtained from octopus contain compounds with chemoprotective properties that reduce the mutagenicity of AFBand proliferation of cancer cell lines. © 2013 Carolina Moreno-Félix et al.
AB - Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using thin layer chromatography (TLC), and each fraction was tested for antimutagenic and antiproliferative activities. Organic extract reduced the number of revertants caused by aflatoxin Bshowing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. Based on the results obtained, the isolated fractions obtained from octopus contain compounds with chemoprotective properties that reduce the mutagenicity of AFBand proliferation of cancer cell lines. © 2013 Carolina Moreno-Félix et al.
U2 - 10.1155/2013/273582
DO - 10.1155/2013/273582
M3 - Article
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
SN - 1741-427X
ER -