TY - JOUR
T1 - Caesalpinia palmeri: First Report on the Phenolic Compounds Profile, Antioxidant and Cytotoxicity Effect
T2 - First Report on the Phenolic Compounds Profile, Antioxidant and Cytotoxicity Effect
AU - López-Romero, J C
AU - Torres-Moreno, H
AU - Vidal-Gutiérrez, M
AU - Cabrera-Cabrera, G G
AU - Robles-Zepeda, R E
AU - Rodríguez-Martínez, K L
AU - Ortega-García, J
AU - Villegas-Ochoa, M A
AU - Salazar-López, Norma J
AU - Domínguez-Avila, J Abraham
AU - González-Aguilar, G A
N1 - Publisher Copyright:
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
PY - 2023/1/20
Y1 - 2023/1/20
N2 - This study aimed to determine the phenolic compounds profile, antioxidant potential and cytotoxicity of extracts and fractions of Caesalpinia palmeri. Methanolic extracts were generated from C. palmeri berries, stems and flowers. The latter was subjected to liquid-liquid partition, obtaining hexane, ethyl acetate and residues fractions. Results showed that the flower extract and ethyl acetate fraction had a larger concentration of phenolic compounds (148.9 and 307.9 mg GAE/g, respectively), being ellagic acid (6233.57 and 19550.08 μg/g, respectively), quercetin-3-β-glycoside (3023.85 and 8952.55 μg/g, respectively) and gallic acid (2212.98 and 8422.34 μg/g, respectively) the most abundant compounds. Flower extract and ethyl acetate fraction also presented the highest antioxidant capacity on all tested methods (DPPH, ABTS, ORAC and FRAP) and low cytotoxicity against ARPE-19 cells (IC50 >170 μg/mL). C. palmeri possessed high antioxidant potential, associated with the presence of phenolic compounds and low cytotoxicity, suggesting that they could represent an option to counter oxidative stress.
AB - This study aimed to determine the phenolic compounds profile, antioxidant potential and cytotoxicity of extracts and fractions of Caesalpinia palmeri. Methanolic extracts were generated from C. palmeri berries, stems and flowers. The latter was subjected to liquid-liquid partition, obtaining hexane, ethyl acetate and residues fractions. Results showed that the flower extract and ethyl acetate fraction had a larger concentration of phenolic compounds (148.9 and 307.9 mg GAE/g, respectively), being ellagic acid (6233.57 and 19550.08 μg/g, respectively), quercetin-3-β-glycoside (3023.85 and 8952.55 μg/g, respectively) and gallic acid (2212.98 and 8422.34 μg/g, respectively) the most abundant compounds. Flower extract and ethyl acetate fraction also presented the highest antioxidant capacity on all tested methods (DPPH, ABTS, ORAC and FRAP) and low cytotoxicity against ARPE-19 cells (IC50 >170 μg/mL). C. palmeri possessed high antioxidant potential, associated with the presence of phenolic compounds and low cytotoxicity, suggesting that they could represent an option to counter oxidative stress.
KW - Caesalpinia palmeri
KW - antioxidants
KW - cytotoxicity
KW - phenolic compounds
UR - http://www.scopus.com/inward/record.url?scp=85143601783&partnerID=8YFLogxK
U2 - 10.1002/cbdv.202200631
DO - 10.1002/cbdv.202200631
M3 - Artículo
C2 - 36423339
SN - 1612-1872
VL - 20
SP - 1
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 1
M1 - e202200631
ER -