Introduction: Pulmonary tuberculosis (TBP) is a chronic infectious disease that impairs the health-related quality of life (HRQOL) of the patients who suffer from it. Sonora ranks second in national morbidity and third in mortality from TBP, but to our knowledge it has not been evaluated how HRQOL affects patients with TBP at the local level. Objective: To evaluate HRQOL in adults ≥ 18 years of age with confirmed TBP seen at health centers in Hermosillo, Sonora. Methods: We carried out a cross-sectional study with 46 subjects, to whom the validated Short Form 36 questionnaire (SF-36v2) was applied to examine their HRQOL. The outcomes were compared according to the variables gender, phase of treatment phase (intensive/support) and comorbidities (present/absent); sociodemographic aspects such as occupation, education and family income were also described. Results: HRQOL was significantly lower in women, patients in intensive phase and those who had comorbidities. The most notorious deterioration occurred in physical aspects and the perception of global health. Conclusion: Subjects with TBP perceived deterioration in their HRQOL, but pharmacological treatment exerts a positive effect on their well-being.
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