Clinical features of patients with rocky mountain spotted fever, dengue and chikungunya infection

Translated title of the contribution: Clinical features of patients with rocky mountain spotted fever, dengue and chikungunya infection

Jesús Delgado-De la Mora, Jesús D. Licona-Enríquez, Diego I. Álvarez-López, Diana E. Aguilar-León, Gerardo Álvarez-Hernández*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Clinical distinction between arbovirus infections and those caused by rickettsia is crucial to initiate appropriate medical treatment. Objective: To compare the differences between Rocky Mountain spotted fever (RMSF) and other vec-tor-borne diseases (dengue and chikungunya) with similar clinical presentation, and to identify data that could aid rapid diagnosis of these diseases. Methods: We evaluated sociodemographic, clinical and laboratory data of 399 patients from five hospitals and clinics of Sonora, Mexico, between 2004 and 2016, with laboratory-confirmed diagnosis of RMSF, dengue, or chikungunya. Results: The RMSF group had the highest lethality (49/63 deaths, 77.8 %), followed by the chikungunya group (3/161, 1.9 %) and the dengue group (3/161, 1.9 %). Clinical differences included the presence of rash, edema, and pruritus; in addition, differences in multiple biomarkers such as platelets, hemoglobin, indirect bilirubin, and serum sodium levels were documented. Conclusion: Rash on the palms and soles, edema and absence of pruritus, together with high levels of direct bilirubin and severe thrombocytopenia could be useful indicators to differentiate patients at RMSF advanced stages from those with dengue and chikungunya.

Translated title of the contributionClinical features of patients with rocky mountain spotted fever, dengue and chikungunya infection
Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalGaceta Medica de Mexico
Volume157
Issue number1
DOIs
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2020 Academia Nacional de Medicina de México, A.C.

Keywords

  • Chikungunya
  • Dengue
  • Mexico
  • Rocky Mountain spotted fever

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