Carboxylated nanodiamond and re-oxygenation process of gamma irradiated red blood cells

M. Acosta-Elías; A. Sarabia-Sainz; S. Pedroso-Santana; E. Silva-Campa; K. Santacruz-Gomez; A. Angulo-Molina; B. Castaneda; D. Soto-Puebla; M. Barboza-Flores; R. Melendrez; S. Álvarez-García; M. Pedroza-Montero

doi:10.1002/pssa.201532197

Carboxylated nanodiamond and re-oxygenation process of gamma irradiated red blood cells

M. Acosta-Elías, A. Sarabia-Sainz, S. Pedroso-Santana, E. Silva-Campa, K. Santacruz-Gomez, A. Angulo-Molina, B. Castaneda, D. Soto-Puebla, M. Barboza-Flores, R. Melendrez, S. Álvarez-García, M. Pedroza-Montero^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Nanodiamonds (NDs) possess exceptional physical, chemical, and biological properties, which make them suitable for potential biomedical applications. They are biocompatible and their usefulness as effective Raman/fluorescence probes for labeling as well as for drug delivery has been demonstrated. Related to their biocompatibility, the interaction between NDs and red blood cells (RBCs) is of great interest. In this work, the influence of carboxylated NDs (cNDs) in the re-oxygenation capability of both γ-irradiated and stored RBCs was studied. The standard 25 Gy γ dose recommended to prevent transfusion associated graft-versus-host disease was used. A 5-day maximum storage time was used to evaluate the “storage lesion”. The hemoglobin (Hb) oxygenation state was assessed by Raman microspectroscopy and the morphologic changes on cells were tracked by optical imaging. Our results show that irradiated RBCs have a better re-oxygenation capability and morphological recovery when they are in presence of cNDs.

Original language	English
Pages (from-to)	2437-2444
Number of pages	8
Journal	Physica Status Solidi (A) Applications and Materials Science
Volume	212
Issue number	11
DOIs	https://doi.org/10.1002/pssa.201532197
State	Published - Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

Raman spectroscopy
diamond
nanomaterials
red blood cells
γ irradiation

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Acosta-Elías, M., Sarabia-Sainz, A., Pedroso-Santana, S., Silva-Campa, E., Santacruz-Gomez, K., Angulo-Molina, A., Castaneda, B., Soto-Puebla, D., Barboza-Flores, M., Melendrez, R., Álvarez-García, S., & Pedroza-Montero, M. (2015). Carboxylated nanodiamond and re-oxygenation process of gamma irradiated red blood cells. Physica Status Solidi (A) Applications and Materials Science, 212(11), 2437-2444. https://doi.org/10.1002/pssa.201532197

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abstract = "Nanodiamonds (NDs) possess exceptional physical, chemical, and biological properties, which make them suitable for potential biomedical applications. They are biocompatible and their usefulness as effective Raman/fluorescence probes for labeling as well as for drug delivery has been demonstrated. Related to their biocompatibility, the interaction between NDs and red blood cells (RBCs) is of great interest. In this work, the influence of carboxylated NDs (cNDs) in the re-oxygenation capability of both γ-irradiated and stored RBCs was studied. The standard 25 Gy γ dose recommended to prevent transfusion associated graft-versus-host disease was used. A 5-day maximum storage time was used to evaluate the “storage lesion”. The hemoglobin (Hb) oxygenation state was assessed by Raman microspectroscopy and the morphologic changes on cells were tracked by optical imaging. Our results show that irradiated RBCs have a better re-oxygenation capability and morphological recovery when they are in presence of cNDs.",

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Acosta-Elías, M, Sarabia-Sainz, A, Pedroso-Santana, S, Silva-Campa, E , Santacruz-Gomez, K , Angulo-Molina, A , Castaneda, B , Soto-Puebla, D , Barboza-Flores, M , Melendrez, R , Álvarez-García, S & Pedroza-Montero, M 2015, 'Carboxylated nanodiamond and re-oxygenation process of gamma irradiated red blood cells', Physica Status Solidi (A) Applications and Materials Science, vol. 212, no. 11, pp. 2437-2444. https://doi.org/10.1002/pssa.201532197

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AU - Acosta-Elías, M.

AU - Sarabia-Sainz, A.

AU - Pedroso-Santana, S.

AU - Silva-Campa, E.

AU - Santacruz-Gomez, K.

AU - Angulo-Molina, A.

AU - Castaneda, B.

AU - Soto-Puebla, D.

AU - Barboza-Flores, M.

AU - Melendrez, R.

AU - Álvarez-García, S.

AU - Pedroza-Montero, M.

PY - 2015/11

Y1 - 2015/11

N2 - Nanodiamonds (NDs) possess exceptional physical, chemical, and biological properties, which make them suitable for potential biomedical applications. They are biocompatible and their usefulness as effective Raman/fluorescence probes for labeling as well as for drug delivery has been demonstrated. Related to their biocompatibility, the interaction between NDs and red blood cells (RBCs) is of great interest. In this work, the influence of carboxylated NDs (cNDs) in the re-oxygenation capability of both γ-irradiated and stored RBCs was studied. The standard 25 Gy γ dose recommended to prevent transfusion associated graft-versus-host disease was used. A 5-day maximum storage time was used to evaluate the “storage lesion”. The hemoglobin (Hb) oxygenation state was assessed by Raman microspectroscopy and the morphologic changes on cells were tracked by optical imaging. Our results show that irradiated RBCs have a better re-oxygenation capability and morphological recovery when they are in presence of cNDs.

AB - Nanodiamonds (NDs) possess exceptional physical, chemical, and biological properties, which make them suitable for potential biomedical applications. They are biocompatible and their usefulness as effective Raman/fluorescence probes for labeling as well as for drug delivery has been demonstrated. Related to their biocompatibility, the interaction between NDs and red blood cells (RBCs) is of great interest. In this work, the influence of carboxylated NDs (cNDs) in the re-oxygenation capability of both γ-irradiated and stored RBCs was studied. The standard 25 Gy γ dose recommended to prevent transfusion associated graft-versus-host disease was used. A 5-day maximum storage time was used to evaluate the “storage lesion”. The hemoglobin (Hb) oxygenation state was assessed by Raman microspectroscopy and the morphologic changes on cells were tracked by optical imaging. Our results show that irradiated RBCs have a better re-oxygenation capability and morphological recovery when they are in presence of cNDs.

KW - Raman spectroscopy

KW - diamond

KW - nanomaterials

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KW - γ irradiation

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DO - 10.1002/pssa.201532197

M3 - Artículo

SN - 1862-6300

VL - 212

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EP - 2444

JO - Physica Status Solidi (A) Applications and Materials Science

JF - Physica Status Solidi (A) Applications and Materials Science

IS - 11

ER -

Carboxylated nanodiamond and re-oxygenation process of gamma irradiated red blood cells

Abstract

Bibliographical note

Keywords

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