Characterization of metal-bound water in bioactive Fe(III)-cyclophane complexes

A. J. Salazar-Medina, R. Gámez-Corrales, J. Z. Ramírez, G. A. González-Aguilar, E. F. Velázquez-Contreras

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

© 2017 The Author(s) Binuclear Fe(III) complexes, Fe2PO and Fe2PC, have functions of antioxidants as well as superoxide dismutase and peroxidase mimickers. The role of water molecules in the non-cytotoxic properties of these complexes have been studied by thermogravimetric and IR/Raman-spectroscopic methods. The thermogravimetric analysis of Fe2PO shows the presence of nine water molecules (Fe2PO·9H2O), three of which are directly coordinated to the metallic ion; the remaining six molecules occupy the secondary coordination sphere. For Fe2PC, eight water molecules were detected (Fe2PC·8H2O), and only one of them directly coordinates to the metallic ion. IR/Raman spectrum analyses corroborate the presence of water molecules in both metallic complexes and the mode of coordination to the ligand, on the basis of bands characteristic of hydration water at ∼3300 cm−1 and bands of adsorbed water between 430 and 490 cm−1. A pentacoordinate geometry is proposed for Fe2PO and a hexacoordinated geometry for Fe2PC. Those results are consistent with theoretical calculations performed through a semiempirical PM7 method. The presence of coordinated water molecules is closely related to the reactivity of Fe2PO and Fe2PC in solution.
Original languageAmerican English
Pages (from-to)225-231
Number of pages7
JournalJournal of Molecular Structure
DOIs
StatePublished - 15 Feb 2018

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