Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel

Leonardo Enrique Valencia Castro; Cinthia Jhovanna Pérez Martínez; Teresa Del Castillo Castro; María Mónica Castillo Ortega; José Carmelo Encinas

doi:10.1002/app.41804

Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel

Leonardo Enrique Valencia Castro, Cinthia Jhovanna Pérez Martínez, Teresa Del Castillo Castro, María Mónica Castillo Ortega, José Carmelo Encinas

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

© 2014 Wiley Periodicals, Inc. Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing L-serine or L-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems.

Original language	English
Journal	Journal of Applied Polymer Science
Volume	132
Issue number	15
DOIs	https://doi.org/10.1002/app.41804 https://doi.org/10.1002/app.41804
State	Published - 1 Jan 2015

Bibliographical note

Cited By :4

Export Date: 23 April 2019

CODEN: JAPNA

Correspondence Address: Del Castillo Castro, T.; Departamento de Investigación en Polímeros y Materiales, Universidad de SonoraMexico

Funding details: Consejo Nacional de Ciencia y Tecnología, CONACYT, 180280

References: Dutta, R.R., Puzari, P., (2014) Biosens. Bioelectron., 52, p. 166; Zeng, J., Huang, Z., Yin, G., Qin, J., Chen, X., Gu, J., (2013) Coll. Surf. B, 110, p. 450; Kim, S.H., Oh, K.W., Bahk, J.H., (2004) J. Appl. Polym. Sci., 91, p. 4064; Ameli, A., Alizadeh, N., (2012) Analyt. Biochem., 428, p. 99; Skotheim, T.A., Reynolds, J.R., (2007) Conjugated Polymers: Processing and Applications, , CRC Press: Boca Raton, USA Chapter 11; Kong, Y., Zhao, W., Yao, S., Xu, J., Wang, W., Chen, Z., (2010) J. Appl. Polym. Sci., 115, p. 1952; Cui, X., Lee, V.A., Raphael, Y., Wiler, J.A., Hetke, J.F., Anderson, D.J., Martin, D.C., (2001) J. Biomed. Mater. Res., 56, p. 261; Deore, B., Chen, Z., Nagaoka, T., (2000) Anal. Chem., 72, p. 3989; Liang, H., Ling, T., Rick, J.F., Chou, T., (2005) Anal. Chim. Acta, 542, p. 83; Syritski, V., Reut, J., Menaker, A., Gyurcsányi, R.E., Opik, A., (2008) Electrochim. Acta, 53, p. 2729; Meteleva-Fischer, Y.V., Von Hauff, E., Parisi, J., (2009) J. Appl. Polym. Sci., 114, p. 4051; Lee, K.Y., Rowley, J.A., Eiselt, P., Moy, E.M., Bouhadir, K.H., Mooney, D., (2000) J. Macromolecules, 33, p. 4291; Ballav, N., Maity, A., Mishra, S.B., (2012) Chem. Eng. J., 198-199, p. 536; Navale, S.T., Mane, A.T., Ghanwat, A.A., Mulik, A.R., Patil, V.B., (2014) Measurements, 50, p. 363; Omastova, M., Trchova, M., Kovarfova, J., Stejskal, J., (2003) Synth. Met., 138, p. 447; Deivanayaki, S., Ponnuswamy, V., Mariappan, R., Jayamurugan, P., (2013) Optik, 124, p. 1089; Jalsovszky, G., Holly, S., Hollosi, M., (1995) J. Mol. Struct., 348, p. 329; Perez-Martínez, C.J., Del Castillo-Castro, T., Castillo-Ortega, M.M., Rodriguez-Felix, D.E., Herrera-Franco, P.J., Ovando-Medina, V.M., (2013) Synth. Met., 184, p. 41; Pigois-Landureau, E., Nicolau, Y.F., Delamar, M., (1995) Synth. Met., 72, p. 111; Ruangchuay, L., Schwank, J., Sirivat, A., (2002) Appl. Surf. Sci., 199, p. 128; Ge, J., Neofytou, E., Cahill, T.J., Beygui, R.E., Zare, R.N., (2012) ACS Nano, 6, p. 227; Derakhsheshpoor, R., Homayoonfal, M., Akbari, A., Reza, M., (2013) J. Environ. Health Sci. Eng., 11, p. 9

Keywords

Conducting polymers
Drug delivery systems
Nanostructured polymers
Amino acids
Ammonium persulfate
Drug delivery
Implants (surgical)
Polypyrroles
Chemical polymerization
Drug delivery applications
Drug delivery system
Electrical stimulations
FT-IR characterization
Implantable devices
Spherical morphologies
Hydrogels

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Castro, L. E. V., Martínez, C. J. P., Del Castillo Castro, T., Ortega, M. M. C., & Encinas, J. C. (2015). Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel. Journal of Applied Polymer Science, 132(15). https://doi.org/10.1002/app.41804, https://doi.org/10.1002/app.41804

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title = "Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel",

abstract = "{\textcopyright} 2014 Wiley Periodicals, Inc. Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing L-serine or L-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems.",

keywords = "Conducting polymers, Drug delivery systems, Nanostructured polymers, Amino acids, Ammonium persulfate, Drug delivery, Implants (surgical), Polypyrroles, Chemical polymerization, Drug delivery applications, Drug delivery system, Electrical stimulations, FT-IR characterization, Implantable devices, Spherical morphologies, Hydrogels",

author = "Castro, {Leonardo Enrique Valencia} and Mart{\'i}nez, {Cinthia Jhovanna P{\'e}rez} and {Del Castillo Castro}, Teresa and Ortega, {Mar{\'i}a M{\'o}nica Castillo} and Encinas, {Jos{\'e} Carmelo}",

note = "Cited By :4 Export Date: 23 April 2019 CODEN: JAPNA Correspondence Address: Del Castillo Castro, T.; Departamento de Investigaci{\'o}n en Pol{\'i}meros y Materiales, Universidad de SonoraMexico Funding details: Consejo Nacional de Ciencia y Tecnolog{\'i}a, CONACYT, 180280 References: Dutta, R.R., Puzari, P., (2014) Biosens. Bioelectron., 52, p. 166; Zeng, J., Huang, Z., Yin, G., Qin, J., Chen, X., Gu, J., (2013) Coll. Surf. B, 110, p. 450; Kim, S.H., Oh, K.W., Bahk, J.H., (2004) J. Appl. Polym. Sci., 91, p. 4064; Ameli, A., Alizadeh, N., (2012) Analyt. Biochem., 428, p. 99; Skotheim, T.A., Reynolds, J.R., (2007) Conjugated Polymers: Processing and Applications, , CRC Press: Boca Raton, USA Chapter 11; Kong, Y., Zhao, W., Yao, S., Xu, J., Wang, W., Chen, Z., (2010) J. Appl. Polym. Sci., 115, p. 1952; Cui, X., Lee, V.A., Raphael, Y., Wiler, J.A., Hetke, J.F., Anderson, D.J., Martin, D.C., (2001) J. Biomed. Mater. Res., 56, p. 261; Deore, B., Chen, Z., Nagaoka, T., (2000) Anal. Chem., 72, p. 3989; Liang, H., Ling, T., Rick, J.F., Chou, T., (2005) Anal. Chim. Acta, 542, p. 83; Syritski, V., Reut, J., Menaker, A., Gyurcs{\'a}nyi, R.E., Opik, A., (2008) Electrochim. Acta, 53, p. 2729; Meteleva-Fischer, Y.V., Von Hauff, E., Parisi, J., (2009) J. Appl. Polym. Sci., 114, p. 4051; Lee, K.Y., Rowley, J.A., Eiselt, P., Moy, E.M., Bouhadir, K.H., Mooney, D., (2000) J. Macromolecules, 33, p. 4291; Ballav, N., Maity, A., Mishra, S.B., (2012) Chem. Eng. J., 198-199, p. 536; Navale, S.T., Mane, A.T., Ghanwat, A.A., Mulik, A.R., Patil, V.B., (2014) Measurements, 50, p. 363; Omastova, M., Trchova, M., Kovarfova, J., Stejskal, J., (2003) Synth. Met., 138, p. 447; Deivanayaki, S., Ponnuswamy, V., Mariappan, R., Jayamurugan, P., (2013) Optik, 124, p. 1089; Jalsovszky, G., Holly, S., Hollosi, M., (1995) J. Mol. Struct., 348, p. 329; Perez-Mart{\'i}nez, C.J., Del Castillo-Castro, T., Castillo-Ortega, M.M., Rodriguez-Felix, D.E., Herrera-Franco, P.J., Ovando-Medina, V.M., (2013) Synth. Met., 184, p. 41; Pigois-Landureau, E., Nicolau, Y.F., Delamar, M., (1995) Synth. Met., 72, p. 111; Ruangchuay, L., Schwank, J., Sirivat, A., (2002) Appl. Surf. Sci., 199, p. 128; Ge, J., Neofytou, E., Cahill, T.J., Beygui, R.E., Zare, R.N., (2012) ACS Nano, 6, p. 227; Derakhsheshpoor, R., Homayoonfal, M., Akbari, A., Reza, M., (2013) J. Environ. Health Sci. Eng., 11, p. 9",

year = "2015",

month = jan,

day = "1",

doi = "10.1002/app.41804",

language = "Ingl{\'e}s",

volume = "132",

journal = "Journal of Applied Polymer Science",

issn = "0021-8995",

publisher = "John Wiley and Sons Inc.",

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Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel. / Castro, Leonardo Enrique Valencia; Martínez, Cinthia Jhovanna Pérez ; Del Castillo Castro, Teresa et al.

In: Journal of Applied Polymer Science, Vol. 132, No. 15, 01.01.2015.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel

AU - Castro, Leonardo Enrique Valencia

AU - Martínez, Cinthia Jhovanna Pérez

AU - Del Castillo Castro, Teresa

AU - Ortega, María Mónica Castillo

AU - Encinas, José Carmelo

N1 - Cited By :4 Export Date: 23 April 2019 CODEN: JAPNA Correspondence Address: Del Castillo Castro, T.; Departamento de Investigación en Polímeros y Materiales, Universidad de SonoraMexico Funding details: Consejo Nacional de Ciencia y Tecnología, CONACYT, 180280 References: Dutta, R.R., Puzari, P., (2014) Biosens. Bioelectron., 52, p. 166; Zeng, J., Huang, Z., Yin, G., Qin, J., Chen, X., Gu, J., (2013) Coll. Surf. B, 110, p. 450; Kim, S.H., Oh, K.W., Bahk, J.H., (2004) J. Appl. Polym. Sci., 91, p. 4064; Ameli, A., Alizadeh, N., (2012) Analyt. Biochem., 428, p. 99; Skotheim, T.A., Reynolds, J.R., (2007) Conjugated Polymers: Processing and Applications, , CRC Press: Boca Raton, USA Chapter 11; Kong, Y., Zhao, W., Yao, S., Xu, J., Wang, W., Chen, Z., (2010) J. Appl. Polym. Sci., 115, p. 1952; Cui, X., Lee, V.A., Raphael, Y., Wiler, J.A., Hetke, J.F., Anderson, D.J., Martin, D.C., (2001) J. Biomed. Mater. Res., 56, p. 261; Deore, B., Chen, Z., Nagaoka, T., (2000) Anal. Chem., 72, p. 3989; Liang, H., Ling, T., Rick, J.F., Chou, T., (2005) Anal. Chim. Acta, 542, p. 83; Syritski, V., Reut, J., Menaker, A., Gyurcsányi, R.E., Opik, A., (2008) Electrochim. Acta, 53, p. 2729; Meteleva-Fischer, Y.V., Von Hauff, E., Parisi, J., (2009) J. Appl. Polym. Sci., 114, p. 4051; Lee, K.Y., Rowley, J.A., Eiselt, P., Moy, E.M., Bouhadir, K.H., Mooney, D., (2000) J. Macromolecules, 33, p. 4291; Ballav, N., Maity, A., Mishra, S.B., (2012) Chem. Eng. J., 198-199, p. 536; Navale, S.T., Mane, A.T., Ghanwat, A.A., Mulik, A.R., Patil, V.B., (2014) Measurements, 50, p. 363; Omastova, M., Trchova, M., Kovarfova, J., Stejskal, J., (2003) Synth. Met., 138, p. 447; Deivanayaki, S., Ponnuswamy, V., Mariappan, R., Jayamurugan, P., (2013) Optik, 124, p. 1089; Jalsovszky, G., Holly, S., Hollosi, M., (1995) J. Mol. Struct., 348, p. 329; Perez-Martínez, C.J., Del Castillo-Castro, T., Castillo-Ortega, M.M., Rodriguez-Felix, D.E., Herrera-Franco, P.J., Ovando-Medina, V.M., (2013) Synth. Met., 184, p. 41; Pigois-Landureau, E., Nicolau, Y.F., Delamar, M., (1995) Synth. Met., 72, p. 111; Ruangchuay, L., Schwank, J., Sirivat, A., (2002) Appl. Surf. Sci., 199, p. 128; Ge, J., Neofytou, E., Cahill, T.J., Beygui, R.E., Zare, R.N., (2012) ACS Nano, 6, p. 227; Derakhsheshpoor, R., Homayoonfal, M., Akbari, A., Reza, M., (2013) J. Environ. Health Sci. Eng., 11, p. 9

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2014 Wiley Periodicals, Inc. Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing L-serine or L-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems.

AB - © 2014 Wiley Periodicals, Inc. Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing L-serine or L-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems.

KW - Conducting polymers

KW - Drug delivery systems

KW - Nanostructured polymers

KW - Amino acids

KW - Ammonium persulfate

KW - Drug delivery

KW - Implants (surgical)

KW - Polypyrroles

KW - Chemical polymerization

KW - Drug delivery applications

KW - Drug delivery system

KW - Electrical stimulations

KW - FT-IR characterization

KW - Implantable devices

KW - Spherical morphologies

KW - Hydrogels

U2 - 10.1002/app.41804

DO - 10.1002/app.41804

M3 - Artículo

VL - 132

JO - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

SN - 0021-8995

IS - 15

ER -

Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel

Abstract

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Keywords

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