Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel

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Abstract

© 2014 Wiley Periodicals, Inc. Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing L-serine or L-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems.
Original languageEnglish
JournalJournal of Applied Polymer Science
Volume132
Issue number15
DOIs
StatePublished - 1 Jan 2015

Bibliographical note

Cited By :4

Export Date: 23 April 2019

CODEN: JAPNA

Correspondence Address: Del Castillo Castro, T.; Departamento de Investigación en Polímeros y Materiales, Universidad de SonoraMexico

Funding details: Consejo Nacional de Ciencia y Tecnología, CONACYT, 180280

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Keywords

  • Conducting polymers
  • Drug delivery systems
  • Nanostructured polymers
  • Amino acids
  • Ammonium persulfate
  • Drug delivery
  • Implants (surgical)
  • Polypyrroles
  • Chemical polymerization
  • Drug delivery applications
  • Drug delivery system
  • Electrical stimulations
  • FT-IR characterization
  • Implantable devices
  • Spherical morphologies
  • Hydrogels

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