Abstract
The development of electro-stimulated drug release devices is an innovative approach to attain the drug delivery in accurate doses at target sites in a programmed manner. In this work, novel electroactive nanocomposite hydrogels were prepared by encapsulating green-synthesized polypyrrole (PPy) colloids within chondroitin sulfate (CS) networks during the self-crosslinking of CS via N-ethyl-N′-(3-dimethylaminopropyl) carbodiimide chemistry. The structural and morphological properties of CS/PPy hydrogels were studied by Fourier-transformed infrared spectroscopy, scanning electron microscopy, and swelling kinetic measurements. The chemotherapeutic agent 5-fluorouracil (5-FU) was loaded into CS/PPy samples by hydrogel swelling method, or alternatively, by pre-incubating the drug in polymer mixture before crosslinking. Different electrical stimulations can be used to switch ON and accurately tune the 5-FU delivery from GG/PPy hydrogels. A single pulse potential of 5 V switched on the drug delivery up to 90% from nanocomposite hydrogel, in contrast to the low 5-FU amount released in a passive form (< 20%). PPy electroactive behavior played a determining role as the main driving force in 5-FU release activation. Cytotoxicity of hydrogels with and without 5-FU was examined in normal and cancer cells. Considering the high cytotoxicity of 5-FU, the ON/OFF 5-FU release patterns evidenced the potential of CS/PPy hydrogels for electrically controlled drug delivery in implantable or transdermal drug release devices.
Original language | English |
---|---|
Pages (from-to) | 621-633 |
Number of pages | 13 |
Journal | Polymers for Advanced Technologies |
Volume | 34 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2023 |
Bibliographical note
Funding Information:Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico, Grant number A1‐S‐26204; Consejo Nacional de Ciencia y Tecnología, Grant/Award Number: A1‐S‐26204 Funding information
Publisher Copyright:
© 2022 John Wiley & Sons Ltd.
Keywords
- 5-fluorouracil
- chondroitin sulfate
- electrically controlled drug release
- electroactive hydrogels
- polypyrrole