Clindamycin-loaded nanofibers of polylactic acid, elastin and gelatin for use in tissue engineering

M. M. Castillo-Ortega, I. Y. López-Peña*, D. E. Rodríguez-Félix, T. Del Castillo-Castro, J. C. Encinas-Encinas, H. Santacruz-Ortega, J. V. Cauich-Rodríguez, J. M. Quiroz-Castillo, L. H. Chan-Chan, I. Lagarda-Diaz, D. F. Plascencia-Martínez, A. A. Leyva-Verduzco

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In the present work, polylactic acid (PLA), elastin and gelatin fibers, containing clindamycin, were prepared to test their potential application as wound dressings. They underwent release studies to determine the mechanism of drug release through mathematical models. The fibers have a homogeneous morphology, without pores. The studies of FTIR and thermal analysis corroborate the presence of each of the components in the fibers; the results of the feasibility tests showed encouraging percentages with a viability of 82% after 7 days of direct contact of the HUVEC cells with the membranes. Similarly, cell adhesion assays show the presence of viable and stretched cells on the fibers, the tendency of the cells to position themselves on the fibers and follow this conformation was observed. On the other hand, studies of antimicrobial activity against S. aureus show us that in fibers loaded with clindamycin they have inhibition halos greater than 8 mm.

Original languageEnglish
Pages (from-to)5495-5513
Number of pages19
JournalPolymer Bulletin
Volume79
Issue number7
DOIs
StatePublished - Jul 2022

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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