Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

Raúl Colorado-Peralta; José Luis Olivares-Romero; Sharon Rosete-Luna; Oscar García-Barradas; Viviana Reyes-Márquez; Delia Hernández-Romero; David Morales-Morales

doi:10.3390/inorganics11050185

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

Raúl Colorado-Peralta, José Luis Olivares-Romero, Sharon Rosete-Luna, Oscar García-Barradas, Viviana Reyes-Márquez, Delia Hernández-Romero^*, David Morales-Morales^*

^*Corresponding author for this work

Departamento de Ciencias Químico-Biológicas

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups have developed novel compounds to solve this problem. Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs. This bibliographical review summarizes the copper complexes that use thiazole and benzothiazole as ligands and that report efficient antimicrobial activity against different bacteria and fungi.

Original language	English
Article number	185
Journal	Inorganics
Volume	11
Issue number	5
DOIs	https://doi.org/10.3390/inorganics11050185
State	Published - May 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

antibacterial
antifungal
azoles
benzothiazole
copper complexes
heterocycles
thiazole

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10.3390/inorganics11050185

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Colorado-Peralta, R., Olivares-Romero, J. L., Rosete-Luna, S., García-Barradas, O., Reyes-Márquez, V., Hernández-Romero, D., & Morales-Morales, D. (2023). Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity. Inorganics, 11(5), Article 185. https://doi.org/10.3390/inorganics11050185

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abstract = "Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups have developed novel compounds to solve this problem. Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs. This bibliographical review summarizes the copper complexes that use thiazole and benzothiazole as ligands and that report efficient antimicrobial activity against different bacteria and fungi.",

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AU - Olivares-Romero, José Luis

AU - Rosete-Luna, Sharon

AU - García-Barradas, Oscar

AU - Reyes-Márquez, Viviana

AU - Hernández-Romero, Delia

AU - Morales-Morales, David

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AB - Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups have developed novel compounds to solve this problem. Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs. This bibliographical review summarizes the copper complexes that use thiazole and benzothiazole as ligands and that report efficient antimicrobial activity against different bacteria and fungi.

KW - antibacterial

KW - antifungal

KW - azoles

KW - benzothiazole

KW - copper complexes

KW - heterocycles

KW - thiazole

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Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

Abstract

Bibliographical note

Keywords

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