Cytotoxic activity of primulasaponin isolated from jacquinia macrocarpa cav. Spp. pungens (a. gray) b. ståhl

Max Vidal Gutiérrez, Heriberto Torres Moreno, Manuel Jiménez-Estrada, Adriana Garibay Escobar, Carlos Arturo Velázquez Contreras, Ramón Enrique Robles-Zepeda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Primulasaponin was isolated from the methanolic extract of the fruit shells of Jacquinia macrocarpa Cav. spp. pungens, and characterized by nuclear magnetic resonance (NMR) and mass spectrometry techniques. The evaluation of the cytotoxic activity was performed by the MTT cell proliferation assay using the cancer cell lines A549, LS180 and HeLa, and the non-cancerous cell line ARPE-19, obtaining the IC 50 of 13.6 µM, 9.3 µM, 23.5 µM, and 22.2 µM respectively. This is the first report of primulasaponin in the genus Jacquinia and its cytotoxic activity in cancer cell lines.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalPharmacologyonline
Volume1
StatePublished - 30 Apr 2020

Bibliographical note

Funding Information:
To Consejo Nacional de Ciencia y Tecnolog?a (CONACyT) for financing this work.

Publisher Copyright:
© 2020, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.

Keywords

  • Cytotoxic activity
  • Jacquinia macrocarpa
  • Primulasaponin
  • Saponin

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