Deep photothermal effect induced by stereotactic laser beams in highly scattering media

L. Baez-Castillo, E. Ortiz-Rascon*, R. C. Carrillo-Torres, N. C. Bruce, J. Garduno-Mejia, A. Lucero-Acuna, M. E. Álvarez-Ramos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Plasmonic photothermal therapy (PPTT), as an increasingly studied treatment alternative, has been widely regarded mostly as a surface tissue treatment choice. Although some techniques have been implemented for interstitial tumors, these involve some grade of invasiveness, as the outer skin is usually broken to introduce light-delivering optical fibers or even catheters. In this work, we present a potential non-invasive strategy using the stereotactic approach, long employed in radiosurgery, by converging multiple near infrared laser beams for PPTT in tissue-equivalent optical phantoms that enclose small gel spheres and simulate interstitial tissue impregnated with plasmonic nanoparticles. The real-time in-depth monitoring of temperature increase is realized by an infrared camera face-on mounted over the phantom. Our results show that a significant reduction in the surface heating can be achieved with this configuration while remarkably increasing the interstitial reach of PPTT, assuring a ~6°C temperature increase for the simulated tumors at 10 mm depth and ~4°C at 15 mm depth and opening up new possibilities for future clinical applications.

Original languageEnglish
Pages (from-to)4248-4251
Number of pages4
JournalOptics Letters
Volume46
Issue number17
DOIs
StatePublished - 1 Sep 2021

Bibliographical note

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©2021 Optical Society of America.

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