Design, assessment, and validation of a questionnaire to estimate food-dependent exercise-induced anaphylaxis prevalence in latin american population

Jhonatan González-Santamaría, Jesús Gilberto Arámburo-Gálvez, Carlos Eduardo Beltrán-Cárdenas, José Antonio Mora-Melgem, Oscar Gerardo Figueroa-Salcido, Giovanni Isaí Ramírez-Torres, Feliznando Isidro Cárdenas-Torres, Itallo Carvalho Gomes, Tatiane Geralda André, María Auxiliadora Macêdo-Callou, Élida Mara Braga Rocha, Noé Ontiveros*, Francisco Cabrera-Chávez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


There are no epidemiological data about food-dependent exercise-induced anaphylaxis (FDEIA) in Latin America. Our aim was to design, assess, and validate a questionnaire to identify potential FDEIA cases and/or estimate its prevalence by self-report. Questions were included in the instrument to address the main symptoms of FDEIA, type/intensity of physical activity, and anaphylaxis. The instrument’s clarity, comprehension and repeatability were evaluated. These evaluations were carried out by Hispanic people (Argentinians/Colombians/Mexicans/Peruvians), including nine individuals with medical diagnosis of FDEIA, and Brazilians. The Flesch–Kincaid score was calculated using the INFLESZ software. The instrument was translated from Spanish to Brazilian Portuguese following the translation back-translation procedure. The participants rated the two versions of the questionnaire as clear and comprehensible (three-point ordinal scale) and very easy to understand [0.33; average (scale 0–10)]. For these evaluations, the Kendall’s W coefficient showed strong agreement among raters (W = 0.80; average). The Flesch–Kincaid score was 63.5 in average (documents considered as readable). The Cohen’s Kappa coefficient showed almost perfect agreement in repeatability (0.88; average). The validation process of two versions of an instrument, used to identify potential FDEIA cases, was successfully carried out and it was found applicable to Latin American countries for generating epidemiological data.

Original languageEnglish
Article number519
JournalHealthcare (Switzerland)
Issue number4
StatePublished - 2020

Bibliographical note

Funding Information:
Acknowledgments: The authors wish to thank CONACyT for the post-graduate fellowship given to J.G.A.-G., O.G.F-S., I.C.G., and T.G.A., as well as INAPI Sinaloa (Young Scientific Talents, 2019 program) for the financial support given to C.E.B.-C. The technical support by Yolanda Irene Aguilar Hinojosa is also acknowledged.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Food-dependent exercise-induced anaphylaxis
  • Questionnaire design
  • Survey studies


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