Detection and partial characterization of antimutagenic compounds from white shrimp (Litopenaeus vannamei) cephalothorax

Héctor Enrique Trujillo-Ruiz, Carmen María López-Saiz, Alejandro Monserrat García-Alegría, Idalia Osuna-Ruiz, Hisila Del Carmen Santacruz-Ortega, María Mercedes Meza-Montenegro, Juan Francisco Maldonado-Escalante, Susana Gabriela Cruz-Ramirez, Armando Burgos Hernández*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Mutations are the result of effects produced by mutagenic agents, which may be responsible for the generation of chronic-degenerative diseases such as cancer. The aim of this work was to detect and characterize compounds with antimutagenic activity in white shrimp (Litopenaeus vannamei) cephalothorax. A serial extraction was carried out where different organic solvents, and its biological activity was evaluated. The antioxidant capacity was evaluated by DPPH and ABTS assay, where the methanol and water-soluble extracts had the highest antioxidant capacity. Antimutagenicity was evaluated by the Ames test, where the methanol-soluble extract showed the highest antimutagenic activity. The methanolic extract was fractionated by open column chromatography, the fractions obtained were determined antioxidant and antimutagenic activity and the ability to protect DNA from oxidative damage. Fraction H27 provided DNA the highest protection against the damage caused by H2O2. Partial chemical-characterization of fraction H27 suggests the presence of aromatic, hydroxylated, unsaturated compounds.

Original languageEnglish
Article number2315990
JournalCYTA - Journal of Food
Issue number1
StatePublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.


  • antimutagenic
  • Antioxidant
  • bioactivity
  • by-product
  • shrimp


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