Diterpenoids and triterpenoids from the resin of bursera microphylla and their cytotoxic activity

Federica Messina, Massimo Curini, Chiara Di Sano, Claudia Zadra, Giulia Gigliarelli, Luisa Alondra Rascón-Valenzuela, Ramón Enrique Robles Zepeda, Maria Carla Marcotullio

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

© 2015 The American Chemical Society and American Society of Pharmacognosy. A chemical study of the nonpolar fraction of a methanol-soluble extract of Bursera microphylla resin yielded a variety of di- and triterpenoids. In total, 15 compounds were isolated, of which three are new, namely, malabaricatrienone (1), malabaricatrienol (2), and microphyllanin (3). The antiproliferative activity of the major compounds was evaluated in different murine cancer cell lines (M12.C3.F6 and RAW264.7) and human cancer cells (A549, HeLa, and PC-3). The new compounds (1-3) did not show significant antiproliferative activity. The known compounds ariensin (4), burseran (5), and dihydroclusin diacetate (6) were effective against the RAW264.7 cell line, with IC<inf>50</inf> values in the micromolar range.
Original languageAmerican English
Pages (from-to)1184-1188
Number of pages5
JournalJournal of Natural Products
DOIs
StatePublished - 22 May 2015

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