Drug Resistance Analysis of Pathogens Isolated from Pediatric Patients in Mexico

Flora Cruz-López, Joaquín Rincón-Zuno, Rayo Morfin-Otero, Eduardo Rodríguez-Noriega, Reyna Edith Corte-Rojas, José Manuel Feliciano-Guzmán, Mariana Gil-Veloz, Lorena Rodríguez-Muñoz, Elena Victoria Choy-Chang, Carlos Miguel Cetina-Umaña, Laura Karina Avilés-Benítez, Adrián Martínez-Meléndez, Esaú López-Jácome, Jesús Silva-Sánchez, Enrique Bolado-Martínez, Maribel López-García, Juan De Dios Castañeda-Duarte, Carmen Lucrecia Ramos-Medellin, Samuel Pavel Escalante-Armenta, Luis Javier Quintanilla-CazaresCarlos Antonio Couoh-May, Sandra Quintana-Ponce, Oscar Alberto Newton-Sánchez, Verónica Rodriguez-Galicia, Dulce María López-López, Guadalupe Soledad Huirache-Villalobos, Jose Luis Ramirez-Mis, Fabián Rojas-Larios, Arely Elizabeth Guerrero-Nuñez, Héctor Miguel Zubiate-Tejada, Lizbeth Soraya Duarte-Miranda, Irma Elena Barroso-Herrera-Y-Cairo, Gerardo Padilla-Rivas, Elvira Garza-González*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective  To analyze the resistance to antimicrobials in clinical isolates from pediatric patients in Mexico. Methods  Susceptibility data from relevant specimens were collected in the pediatric population over 6 months from 25 centers from 17 states of Mexico and analyzed using the WHONET 5.6 software. Data were stratified into three age groups: younger than 2 years, 2 to 6 years, and 6 to 18 years. Results  For Escherichia coli, the infant/toddler group had higher resistance rates to ampicillin, ampicillin-sulbactam, cefuroxime, cefepime, gentamicin, quinolones (p < 0.001), amoxicillin/clavulanic acid (p = 0.003), and ceftazidime (p = 0.004) than the other two age groups. Additionally, a high proportion of extended-spectrum β-lactamase (ESBL)-producing isolates for E. coli (75.3%) was detected in this age group. Comparable results were observed for Klebsiella pneumoniae, with higher resistance to ampicillin-sulbactam, ceftazidime, gentamicin, cefepime, trimethoprim-sulfamethoxazole, carbapenems (p = 0.001) and amoxicillin/clavulanic acid (p = 0.023) in the infant/toddler group. Moreover, a high proportion of ESBL producers (76%) was detected in this age group. Regarding wards, E. coli and K. pneumoniae had the highest carbapenem resistance in the ICU area, and Acinetobacter baumannii had the highest carbapenem resistance in medical wards. Conclusion  High antibiotic resistance rates were detected in the infant/toddler group. This report presents baseline data for future prospective surveillance studies of antimicrobial resistance in pediatric patients in Mexico.

Original languageEnglish
JournalJournal of Pediatric Infectious Diseases
StateAccepted/In press - 2023

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© 2023 Georg Thieme Verlag. All rights reserved.


  • antimicrobial resistance
  • carbapenem-resistant Enterobacterales
  • methicillin-resistant
  • pediatric patients


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