EFECTO DE LA SUPLEMENTACION CON UNA DOSIS MASIVA DE VITAMINA A EN NINOS DE 6 A 36 MESES DE EDAD

Translated title of the contribution: Effect of massive vitamin A supplement in children from 6 to 36 months of age

Alma E. Robles-Sardin, Humberto Astiazarán-García, Reyna Dávalos-Navarro, Luis Quihui-Cota, Rosa Ma Cabrera-Pacheco, Mauro E. Valencia*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective. To evaluate the impact of a single massive dose of vitamin A on the vitamin and iron status in children of margined urban areas in Hermosillo, Sonora, Mexico. Material and methods. A total of 60 children received one dose of 100 000 IU (children from 6 to 12 months) and of 200 000 IU (children from 12 to 36 months) of retinol palmitate distributed by the Health Ministry in June, 1994. Serum levels of retinol, carotenoids, iron, transferrin and ferritin were measured at three periods: basal, after two weeks and after three months. Results. The mean for retinol basal values was 0.7 μmol/l, after two weeks it was 0.97 μmol/l (p<0.0 1) and after three months it was 0.83 μmol/l (p>0.05).When basal values were measured, 6.3% of the children showed severe vitamin A deficiency, which disappeared in the periods following the supplement; additionally, 42% showed moderate deficiency which had decreased to less than 7% after three months. No differences were found for serum iron and transferrin levels (p>0.05), however, ferritin levels increased (p<0.001) after three months indicating an improvement in iron reserves. Conclusions. Massive dose distribution may have an important impact on vitamin a and iron status in children.

Translated title of the contributionEffect of massive vitamin A supplement in children from 6 to 36 months of age
Original languageSpanish
Pages (from-to)309-315
Number of pages7
JournalSalud publica de Mexico
Volume40
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

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