Effect of freeze-thawing conditions for preparation of chitosan-poly (vinyl alcohol) hydrogels and drug release studies

M. D. Figueroa-Pizano, I. Velaz, F. J. Penas, P. Zavala-Rivera, A. J. Rosas-Durazo, A. D. Maldonado-Arce, M. E. Martinez-Barbosa

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

The freezing-thawing is an advantageous method to produce hydrogels without crosslinking agents. In this study chitosan-poly(vinyl alcohol) (CS-PVA) hydrogels were prepared by varying the freezing conditions and composition, which affect the final characteristics of the products. The swelling degree, morphology, porosity, and diflunisal drug loading, as well as the drug release profiles were evaluated. The hydrogel swelling ratio was found to be mainly affected by the CS content, the number of freezing cycles and the temperature. SEM micrographs and porosity data confirm that pore size increases with the chitosan content. However, the use of either lower temperatures or longer freezing times, results in higher porosity and smaller pores. The drug release times of the CS-PVA hydrogels were as long as 30 h, and according to the mathematical fitting, a simple diffusion mechanism dominates the process. Moreover, a mathematical model predicting the hydrogels physical and structural behavior is proposed.

Original languageEnglish
Pages (from-to)476-485
Number of pages10
JournalCarbohydrate Polymers
Volume195
DOIs
StatePublished - 1 Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Chitosan-PVA hydrogels
  • Freezing-thawing method
  • Swelling and porosimetry
  • Drug release
  • Diflunisal
  • Mathematical model

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