Effect of Physiological Fluid on the Photothermal Properties of Gold Nanostructured

María Fernanda Amézaga González, Jazzely Acosta Bezada, Víctor Gómez Flores, Christian Chapa González, Jose Rurik Farias Mancilla, S. J. Castillo, Carlos Avila Orta, Perla E. García-Casillas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Colloidal gold particles have been extensively studied for their potential in hyperthermia treatment due to their ability to become excited in the presence of an external laser. However, their light-to-heat efficiency is affected by the physiologic environment. In this study, we aimed to evaluate the ability of gold sphere, rod, and star-shaped colloids to elevate the temperature of blood plasma and breast cancer-simulated fluid under laser stimulation. Additionally, the dependence of optical properties and colloid stability of gold nanostructures with physiological medium, particle shape, and coating was determined. The light-to-heat efficiency of the gold particle is shape-dependent. The light-to-heat conversion efficiency of a star-shaped colloid is 36% higher than that of sphere-shaped colloids. However, the raised temperature of the surrounding medium is the lowest in the star-shaped colloid. When gold nanostructures are exited with a laser stimulation in a physiological fluid, the ions/cations attach to the surface of the gold particles, resulting in colloidal instability, which limits electron oscillation and diminishes the energy generated by the plasmonic excitation. Fluorescein (Fl) and polyethylene glycol (PEG) attached to gold spheres enhances their colloidal stability and light-to-heat efficiency; post-treatment, they remand their optical properties.

Original languageEnglish
Article number8339
JournalInternational Journal of Molecular Sciences
Issue number9
StatePublished - May 2023

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© 2023 by the authors.


  • gold nanoparticles
  • light-to-heat efficiency
  • photothermal properties


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