Effectiveness of a Lifestyle Change Program on Insulin Resistance in Yaquis Indigenous Populations in Sonora, Mexico: PREVISY

Alejandro Arturo Castro-Juarez, Araceli Serna-Gutiérrez, Heliodoro Alemán-Mateo, Ana Cristina Gallegos-Aguilar, Norma Alicia Dórame-López, Abraham Valenzuela-Sánchez, Diana Marcela Valenzuela-Guzmán, Rolando Giovanni Díaz-Zavala, Rene Urquidez-Romero, Julián Esparza-Romero*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


To evaluate the effectiveness of the healthy lifestyle promotion program for Yaquis (PREVISY) on insulin resistance in the short- and medium-term periods in adults who are overweight/obese and have an increased risk for diabetes. Using a translational research design, an intervention program was implemented in a sample of 93 Yaqui adult subjects. The effectiveness of PREVISY was evaluated by comparing the levels of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and the Triglycerides-Glucose Index (TyG index) at 6 and 12 months using a paired t-test. Results: In the subjects who completed the program, a decrease in the HOMA-IR index (∆ = −0.91 and ∆ = −1.29, p ≤ 0.05) and the TyG index (∆ = −0.24 y ∆ = −0.20, p ≤ 0.05) was observed in the short- and medium-term period, respectively. Subjects with body weight loss ≥ 10% showed decreased levels of HOMA-IR (∆ = −3.32 and ∆ = −4.89, p ≤ 0.05) and the TyG index (∆ = −0.80 and ∆ = −0.60, p ≤ 0.05) at 6 and 12 months, respectively. A stronger benefit of the program was found in subjects with obesity (vs. overweight) and with high and very high risk of diabetes (vs. moderate risk) in IR markers (p ≤ 0.05). The PREVISY program demonstrated its effectiveness in the improvement of some markers of insulin resistance in Yaqui adults at risk of diabetes.

Original languageEnglish
Article number597
Issue number3
StatePublished - Feb 2023

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  • Yaqui indigenous
  • insulin resistance
  • prevention
  • type 2 diabetes


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