Electroconductive nanocomposite hydrogel for pulsatile drug release

C. J. Pérez-Martínez; Sergio Daniel Morales Chávez; T. Del Castillo-Castro; Tania Ernestina Lara Ceniceros; M. M. Castillo-Ortega; D. E. Rodríguez-Félix; Juan Carlos Gálvez Ruiz

doi:10.1016/j.reactfunctpolym.2015.12.017

Electroconductive nanocomposite hydrogel for pulsatile drug release

C. J. Pérez-Martínez, Sergio Daniel Morales Chávez, T. Del Castillo-Castro, Tania Ernestina Lara Ceniceros, M. M. Castillo-Ortega, D. E. Rodríguez-Félix, Juan Carlos Gálvez Ruiz

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

© 2015 Elsevier B.V. All rights reserved. Polyacrylamide (PAAm) hydrogel containing nanofibers of polyaniline (PANI) has been prepared in order to evaluate it as electric stimuli-responsive material. Amoxicillin was loaded onto chemically synthesized PANI nanofibers of large-aspect-ratio. Composite hydrogel was obtained by the in situ incorporation of amoxicillin-loaded PANI during polymerization and reticulation of acrylamide. TEM images of cross sections of PAAm/amoxicillin-loaded PANI composite revealed a continuous 3D nanofiber network of PANI supported by the hydrogel matrix. The antibiotic molecules were accurately released (or sustained) from composite hydrogel in response to application (or removal) of cathodic electrical stimulation. In vitro cytotoxicity evaluation of composite hydrogel extract on mouse subcutaneous connective tissue has shown cell viability higher than 80%. The tuning release profile and minimal toxicity of the material evidenced its potential for electrically controlled drug delivery applications such as implantable devices and transdermal drug delivery systems.

Original language	American English
Pages (from-to)	12-17
Number of pages	6
Journal	Reactive and Functional Polymers
Volume	100
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2015.12.017 https://doi.org/10.1016/j.reactfunctpolym.2015.12.017
State	Published - 1 Mar 2016

Bibliographical note

Cited By :15

Export Date: 23 April 2019

CODEN: RFPOF

Correspondence Address: Del Castillo-Castro, T.; Departamento de Investigación en Polímeros y Materiales, Universidad de SonoraMexico; email: [email protected]

Funding details: Consejo Nacional de Ciencia y Tecnología, 2012-N°180280

Funding text 1: This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico (Grant Ciencia Básica 2012-N°180280 ). C. J. Pérez-Martínez and Sergio Daniel Morales Chávez acknowledge CONACYT for the scholarship during this study.

References: Rivero, R.E., Molina, M.A., Rivarola, C.R., Barbero, C.A., (2014) Sensors Actuators B, 190, pp. 270-278; Dispenza, C., Fiandaca, G., Lo Presti, C., Piazza, S., Spadaro, G., (2007) Radiat. Phys. Chem., 76, pp. 1371-1375; Verma, P.K., Sardar, P.S., Ghosh, S., Biswas, M., (2009) Polym. Compos., 30, pp. 490-496; Owino, J.H., Arotiba, O.A., Baker, P.G., Guiseppi-Elie, A., Iwuoha, E.I., (2008) React. Funct. Polym., 68, pp. 1239-1244; Wang, Y., Yang, X., Qiu, L., Li, D., (2013) Energy Environ. Sci., 6, pp. 477-481; Kotanen, C.N., Tlili, C., Guiseppi-Elie, A., (2013) Talanta, 103, pp. 228-235; Brahima, S., Narinesingha, D., Guiseppi-Elie, A., (2002) Biosens. Bioelectron., 17, pp. 53-59; Zhang, L., Li, Y., Li, L., Guo, B., Ma, P.X., (2014) React. Funct. Polym., 82, pp. 81-88; Kotanen, C.N., Wilson, A.N., Dong, C., Dinu, C.Z., Justin, G.A., Guiseppi-Elie, A., (2013) Biomaterials, 34, pp. 6318-6327; Chansai, P., Sirivat, A., Niamlang, S., Chotpattananont, D., Viravaidya-Pasuwat, K., (2009) Int. J. Pharm., 381, pp. 25-33; Tsai, T.S., Pillay, V., Choonara, Y.E., Du Toit, L.C., Modi, G., Naidoo, D., Kumar, P., (2011) Polymers, 3, pp. 150-172; Guiseppi-Elie, A., (2010) Biomaterials, 31, pp. 2701-2716; Sharma, K., Kaith, B.S., Kumar, V., Kalia, S., Kumar, V., Swart, H.C., (2014) Geoderma, 232-234, pp. 45-55; Low, L.M., Seetharaman, S., He, K.Q., Madou, M.J., (2000) Sensors Actuators B, 67, pp. 149-160; Niamlang, S., Sirivat, A., (2009) Int. J. Pharm., 371, pp. 126-133; Lira, L.M., De Torresi, S.I., (2008) Sensors Actuators B, 130, pp. 638-644; Ge, J., Neofytou, E., Cahill, T.J., Beygui, R.E., Zare, R.N., (2012) ACS Nano, 6, pp. 227-233; Pérez, C.J., Del Castillo, T., Castillo, M.M., Rodríguez, D.E., Herrera, P.J., Ovando, V.M., (2013) Synth. Met., 184, pp. 41-47; Ivanova, V.T., Katrukha, G.S., Timofeeva, A.V., Ilyna, M.V., Kurochkina, Y.E., Baratova, L.A., Sapurina, I.Y., Ivanov, V.F., (2011) J. Phys. Conf. Ser., 291, p. 012004; Javadian, H., (2014) J. Ind. Eng. Chem., 20, pp. 4233-4241; Karthik, R., Meenakshi, S., (2015) Chem. Eng. J., 263, pp. 168-177; Debnath, S., Ballav, N., Maity, A., Pillay, K., (2015) Int. J. Biol. Macromol., 72, pp. 732-739; Debnath, S., Ballav, N., Maity, A., Pillay, K., (2015) Int. J. Biol. Macromol., 75, pp. 199-209; Nath, B.C., Gogoi, B., Boruah, M., Sharma, S., Khannam, M., Ahmed, G.A., Dolui, S.K., (2014) Electrochim. Acta, 146, pp. 106-111; Dai, T., Qing, X., Wang, J., Shen, C., Lu, Y., (2010) Compos. Sci. Technol., 70, pp. 498-503; Zhao, Y.X., Ren, K.F., Sun, Y.X., Li, Z.J., Ji, J., (2014) RSC Adv., 4, pp. 24511-24517; Słoniewska, A., Pałys, B., (2014) Electrochim. Acta, 126, pp. 90-97; Kwon, I.C., Bae, Y.H., Kim, S.W., Control, J., (1994) Release, 30, pp. 155-159; Sutani, K., Kaetsu, I., Uchida, K., (2001) Radiat. Phys. Chem., 61, pp. 49-54; Murdan, S., Control, J., (2003) Release, 92, pp. 1-17; Indermun, S., Choonara, Y.E., Kumar, P., Du Toit, L.C., Modi, G., Luttge, R., Pillay, V., (2014) Int. J. Pharm., 462, pp. 52-65; Derakhsheshpoor, R., Homayoonfal, M., Akbari, A., Reza, M.J., (2013) J. Environ. Health Sci. Eng., 11, p. 9; Jeon, G., Yang, S.Y., Byun, J., Kim, J.K., (2011) Nano Lett., 11, pp. 1284-1288; Ricka, J., Tanaka, T., (1984) Macromolecules, 17, pp. 2916-2921; Yang, Y., Engberts, J.B.F.N., (2000) Colloids Surf. A, 169, pp. 85-94; Takahashi, S.H., Lira, L.M., De Torresi, S.I.C., (2012) J. Biomater. Bionanotechnol., 3, pp. 262-268; Siepmann, J., Peppas, N.A., (2001) Adv. Drug Deliv. Rev., 48, pp. 139-157; Bus, J.S., Popp, J.A., (1987) Food Chem. Toxicol., 25, pp. 619-626; Dispenza, C., Sabatino, M.A., Niconov, A., Chmielewska, D., Spadaro, G., (2012) Radiat. Phys. Chem., 81, pp. 1456-1459; Mattioli, M., Giavaresi, G., Biagini, G., Virgili, L., Giacomini, M., Fini, M., Giantomassi, F., Giardino, R., (2003) Int. J. Artif. Organs, 26, pp. 1077-1085; Bidez, P.R., Li, S., MacDiarmid, A.G., Venancio, E.C., Wei, Y., Lelkes, P.I., (2006) J. Biomater. Sci. Polym. Ed., 17, pp. 199-212; Qazi, T.H., Rai, R., Boccaccini, A.R., (2014) Biomaterials, 35, pp. 9068-9086

Keywords

Electrically controlled drug release
Electroconductive hydrogels
Electroconductive polymer
Acrylic monomers
Aspect ratio
Collagen
Conducting polymers
Controlled drug delivery
Drug products
Electric conductivity
Implants (surgical)
Musculoskeletal system
Nanofibers
Polyaniline
Composite hydrogels
Controlled drug release
Drug delivery applications
Electrical stimulations
Electroconductive
Electroconductive polymers
Nanocomposite hydrogels
Transdermal drug delivery systems
Hydrogels

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Pérez-Martínez, C. J., Morales Chávez, S. D., Del Castillo-Castro, T., Lara Ceniceros, T. E., Castillo-Ortega, M. M., Rodríguez-Félix, D. E., & Gálvez Ruiz, J. C. (2016). Electroconductive nanocomposite hydrogel for pulsatile drug release. Reactive and Functional Polymers, 100, 12-17. https://doi.org/10.1016/j.reactfunctpolym.2015.12.017, https://doi.org/10.1016/j.reactfunctpolym.2015.12.017

@article{dfdb5e1bd5b8482591c0acf024a61ae7,

title = "Electroconductive nanocomposite hydrogel for pulsatile drug release",

abstract = "{\textcopyright} 2015 Elsevier B.V. All rights reserved. Polyacrylamide (PAAm) hydrogel containing nanofibers of polyaniline (PANI) has been prepared in order to evaluate it as electric stimuli-responsive material. Amoxicillin was loaded onto chemically synthesized PANI nanofibers of large-aspect-ratio. Composite hydrogel was obtained by the in situ incorporation of amoxicillin-loaded PANI during polymerization and reticulation of acrylamide. TEM images of cross sections of PAAm/amoxicillin-loaded PANI composite revealed a continuous 3D nanofiber network of PANI supported by the hydrogel matrix. The antibiotic molecules were accurately released (or sustained) from composite hydrogel in response to application (or removal) of cathodic electrical stimulation. In vitro cytotoxicity evaluation of composite hydrogel extract on mouse subcutaneous connective tissue has shown cell viability higher than 80%. The tuning release profile and minimal toxicity of the material evidenced its potential for electrically controlled drug delivery applications such as implantable devices and transdermal drug delivery systems.",

keywords = "Electrically controlled drug release, Electroconductive hydrogels, Electroconductive polymer, Acrylic monomers, Aspect ratio, Collagen, Conducting polymers, Controlled drug delivery, Drug products, Electric conductivity, Implants (surgical), Musculoskeletal system, Nanofibers, Polyaniline, Composite hydrogels, Controlled drug release, Drug delivery applications, Electrical stimulations, Electroconductive, Electroconductive polymers, Nanocomposite hydrogels, Transdermal drug delivery systems, Hydrogels",

author = "P{\'e}rez-Mart{\'i}nez, {C. J.} and {Morales Ch{\'a}vez}, {Sergio Daniel} and {Del Castillo-Castro}, T. and {Lara Ceniceros}, {Tania Ernestina} and Castillo-Ortega, {M. M.} and Rodr{\'i}guez-F{\'e}lix, {D. E.} and {G{\'a}lvez Ruiz}, {Juan Carlos}",

note = "Cited By :15 Export Date: 23 April 2019 CODEN: RFPOF Correspondence Address: Del Castillo-Castro, T.; Departamento de Investigaci{\'o}n en Pol{\'i}meros y Materiales, Universidad de SonoraMexico; email: [email protected] Funding details: Consejo Nacional de Ciencia y Tecnolog{\'i}a, 2012-N°180280 Funding text 1: This work was supported by the Consejo Nacional de Ciencia y Tecnolog{\'i}a (CONACYT), Mexico (Grant Ciencia B{\'a}sica 2012-N°180280 ). C. J. P{\'e}rez-Mart{\'i}nez and Sergio Daniel Morales Ch{\'a}vez acknowledge CONACYT for the scholarship during this study. References: Rivero, R.E., Molina, M.A., Rivarola, C.R., Barbero, C.A., (2014) Sensors Actuators B, 190, pp. 270-278; Dispenza, C., Fiandaca, G., Lo Presti, C., Piazza, S., Spadaro, G., (2007) Radiat. Phys. Chem., 76, pp. 1371-1375; Verma, P.K., Sardar, P.S., Ghosh, S., Biswas, M., (2009) Polym. Compos., 30, pp. 490-496; Owino, J.H., Arotiba, O.A., Baker, P.G., Guiseppi-Elie, A., Iwuoha, E.I., (2008) React. Funct. Polym., 68, pp. 1239-1244; Wang, Y., Yang, X., Qiu, L., Li, D., (2013) Energy Environ. Sci., 6, pp. 477-481; Kotanen, C.N., Tlili, C., Guiseppi-Elie, A., (2013) Talanta, 103, pp. 228-235; Brahima, S., Narinesingha, D., Guiseppi-Elie, A., (2002) Biosens. Bioelectron., 17, pp. 53-59; Zhang, L., Li, Y., Li, L., Guo, B., Ma, P.X., (2014) React. Funct. Polym., 82, pp. 81-88; Kotanen, C.N., Wilson, A.N., Dong, C., Dinu, C.Z., Justin, G.A., Guiseppi-Elie, A., (2013) Biomaterials, 34, pp. 6318-6327; Chansai, P., Sirivat, A., Niamlang, S., Chotpattananont, D., Viravaidya-Pasuwat, K., (2009) Int. J. Pharm., 381, pp. 25-33; Tsai, T.S., Pillay, V., Choonara, Y.E., Du Toit, L.C., Modi, G., Naidoo, D., Kumar, P., (2011) Polymers, 3, pp. 150-172; Guiseppi-Elie, A., (2010) Biomaterials, 31, pp. 2701-2716; Sharma, K., Kaith, B.S., Kumar, V., Kalia, S., Kumar, V., Swart, H.C., (2014) Geoderma, 232-234, pp. 45-55; Low, L.M., Seetharaman, S., He, K.Q., Madou, M.J., (2000) Sensors Actuators B, 67, pp. 149-160; Niamlang, S., Sirivat, A., (2009) Int. J. Pharm., 371, pp. 126-133; Lira, L.M., De Torresi, S.I., (2008) Sensors Actuators B, 130, pp. 638-644; Ge, J., Neofytou, E., Cahill, T.J., Beygui, R.E., Zare, R.N., (2012) ACS Nano, 6, pp. 227-233; P{\'e}rez, C.J., Del Castillo, T., Castillo, M.M., Rodr{\'i}guez, D.E., Herrera, P.J., Ovando, V.M., (2013) Synth. Met., 184, pp. 41-47; Ivanova, V.T., Katrukha, G.S., Timofeeva, A.V., Ilyna, M.V., Kurochkina, Y.E., Baratova, L.A., Sapurina, I.Y., Ivanov, V.F., (2011) J. Phys. Conf. Ser., 291, p. 012004; Javadian, H., (2014) J. Ind. Eng. Chem., 20, pp. 4233-4241; Karthik, R., Meenakshi, S., (2015) Chem. Eng. J., 263, pp. 168-177; Debnath, S., Ballav, N., Maity, A., Pillay, K., (2015) Int. J. Biol. Macromol., 72, pp. 732-739; Debnath, S., Ballav, N., Maity, A., Pillay, K., (2015) Int. J. Biol. Macromol., 75, pp. 199-209; Nath, B.C., Gogoi, B., Boruah, M., Sharma, S., Khannam, M., Ahmed, G.A., Dolui, S.K., (2014) Electrochim. Acta, 146, pp. 106-111; Dai, T., Qing, X., Wang, J., Shen, C., Lu, Y., (2010) Compos. Sci. Technol., 70, pp. 498-503; Zhao, Y.X., Ren, K.F., Sun, Y.X., Li, Z.J., Ji, J., (2014) RSC Adv., 4, pp. 24511-24517; S{\l}oniewska, A., Pa{\l}ys, B., (2014) Electrochim. Acta, 126, pp. 90-97; Kwon, I.C., Bae, Y.H., Kim, S.W., Control, J., (1994) Release, 30, pp. 155-159; Sutani, K., Kaetsu, I., Uchida, K., (2001) Radiat. Phys. Chem., 61, pp. 49-54; Murdan, S., Control, J., (2003) Release, 92, pp. 1-17; Indermun, S., Choonara, Y.E., Kumar, P., Du Toit, L.C., Modi, G., Luttge, R., Pillay, V., (2014) Int. J. Pharm., 462, pp. 52-65; Derakhsheshpoor, R., Homayoonfal, M., Akbari, A., Reza, M.J., (2013) J. Environ. Health Sci. Eng., 11, p. 9; Jeon, G., Yang, S.Y., Byun, J., Kim, J.K., (2011) Nano Lett., 11, pp. 1284-1288; Ricka, J., Tanaka, T., (1984) Macromolecules, 17, pp. 2916-2921; Yang, Y., Engberts, J.B.F.N., (2000) Colloids Surf. A, 169, pp. 85-94; Takahashi, S.H., Lira, L.M., De Torresi, S.I.C., (2012) J. Biomater. Bionanotechnol., 3, pp. 262-268; Siepmann, J., Peppas, N.A., (2001) Adv. Drug Deliv. Rev., 48, pp. 139-157; Bus, J.S., Popp, J.A., (1987) Food Chem. Toxicol., 25, pp. 619-626; Dispenza, C., Sabatino, M.A., Niconov, A., Chmielewska, D., Spadaro, G., (2012) Radiat. Phys. Chem., 81, pp. 1456-1459; Mattioli, M., Giavaresi, G., Biagini, G., Virgili, L., Giacomini, M., Fini, M., Giantomassi, F., Giardino, R., (2003) Int. J. Artif. Organs, 26, pp. 1077-1085; Bidez, P.R., Li, S., MacDiarmid, A.G., Venancio, E.C., Wei, Y., Lelkes, P.I., (2006) J. Biomater. Sci. Polym. Ed., 17, pp. 199-212; Qazi, T.H., Rai, R., Boccaccini, A.R., (2014) Biomaterials, 35, pp. 9068-9086",

year = "2016",

month = mar,

day = "1",

doi = "10.1016/j.reactfunctpolym.2015.12.017",

language = "American English",

volume = "100",

pages = "12--17",

journal = "Reactive and Functional Polymers",

issn = "1381-5148",

publisher = "Elsevier",

}

Pérez-Martínez, CJ, Morales Chávez, SD, Del Castillo-Castro, T, Lara Ceniceros, TE, Castillo-Ortega, MM, Rodríguez-Félix, DE & Gálvez Ruiz, JC 2016, 'Electroconductive nanocomposite hydrogel for pulsatile drug release', Reactive and Functional Polymers, vol. 100, pp. 12-17. https://doi.org/10.1016/j.reactfunctpolym.2015.12.017, https://doi.org/10.1016/j.reactfunctpolym.2015.12.017

TY - JOUR

T1 - Electroconductive nanocomposite hydrogel for pulsatile drug release

AU - Pérez-Martínez, C. J.

AU - Morales Chávez, Sergio Daniel

AU - Del Castillo-Castro, T.

AU - Lara Ceniceros, Tania Ernestina

AU - Castillo-Ortega, M. M.

AU - Rodríguez-Félix, D. E.

AU - Gálvez Ruiz, Juan Carlos

N1 - Cited By :15 Export Date: 23 April 2019 CODEN: RFPOF Correspondence Address: Del Castillo-Castro, T.; Departamento de Investigación en Polímeros y Materiales, Universidad de SonoraMexico; email: [email protected] Funding details: Consejo Nacional de Ciencia y Tecnología, 2012-N°180280 Funding text 1: This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico (Grant Ciencia Básica 2012-N°180280 ). C. J. Pérez-Martínez and Sergio Daniel Morales Chávez acknowledge CONACYT for the scholarship during this study. References: Rivero, R.E., Molina, M.A., Rivarola, C.R., Barbero, C.A., (2014) Sensors Actuators B, 190, pp. 270-278; Dispenza, C., Fiandaca, G., Lo Presti, C., Piazza, S., Spadaro, G., (2007) Radiat. Phys. Chem., 76, pp. 1371-1375; Verma, P.K., Sardar, P.S., Ghosh, S., Biswas, M., (2009) Polym. Compos., 30, pp. 490-496; Owino, J.H., Arotiba, O.A., Baker, P.G., Guiseppi-Elie, A., Iwuoha, E.I., (2008) React. Funct. Polym., 68, pp. 1239-1244; Wang, Y., Yang, X., Qiu, L., Li, D., (2013) Energy Environ. Sci., 6, pp. 477-481; Kotanen, C.N., Tlili, C., Guiseppi-Elie, A., (2013) Talanta, 103, pp. 228-235; Brahima, S., Narinesingha, D., Guiseppi-Elie, A., (2002) Biosens. Bioelectron., 17, pp. 53-59; Zhang, L., Li, Y., Li, L., Guo, B., Ma, P.X., (2014) React. Funct. Polym., 82, pp. 81-88; Kotanen, C.N., Wilson, A.N., Dong, C., Dinu, C.Z., Justin, G.A., Guiseppi-Elie, A., (2013) Biomaterials, 34, pp. 6318-6327; Chansai, P., Sirivat, A., Niamlang, S., Chotpattananont, D., Viravaidya-Pasuwat, K., (2009) Int. J. Pharm., 381, pp. 25-33; Tsai, T.S., Pillay, V., Choonara, Y.E., Du Toit, L.C., Modi, G., Naidoo, D., Kumar, P., (2011) Polymers, 3, pp. 150-172; Guiseppi-Elie, A., (2010) Biomaterials, 31, pp. 2701-2716; Sharma, K., Kaith, B.S., Kumar, V., Kalia, S., Kumar, V., Swart, H.C., (2014) Geoderma, 232-234, pp. 45-55; Low, L.M., Seetharaman, S., He, K.Q., Madou, M.J., (2000) Sensors Actuators B, 67, pp. 149-160; Niamlang, S., Sirivat, A., (2009) Int. J. Pharm., 371, pp. 126-133; Lira, L.M., De Torresi, S.I., (2008) Sensors Actuators B, 130, pp. 638-644; Ge, J., Neofytou, E., Cahill, T.J., Beygui, R.E., Zare, R.N., (2012) ACS Nano, 6, pp. 227-233; Pérez, C.J., Del Castillo, T., Castillo, M.M., Rodríguez, D.E., Herrera, P.J., Ovando, V.M., (2013) Synth. Met., 184, pp. 41-47; Ivanova, V.T., Katrukha, G.S., Timofeeva, A.V., Ilyna, M.V., Kurochkina, Y.E., Baratova, L.A., Sapurina, I.Y., Ivanov, V.F., (2011) J. Phys. Conf. Ser., 291, p. 012004; Javadian, H., (2014) J. Ind. Eng. Chem., 20, pp. 4233-4241; Karthik, R., Meenakshi, S., (2015) Chem. Eng. J., 263, pp. 168-177; Debnath, S., Ballav, N., Maity, A., Pillay, K., (2015) Int. J. Biol. Macromol., 72, pp. 732-739; Debnath, S., Ballav, N., Maity, A., Pillay, K., (2015) Int. J. Biol. Macromol., 75, pp. 199-209; Nath, B.C., Gogoi, B., Boruah, M., Sharma, S., Khannam, M., Ahmed, G.A., Dolui, S.K., (2014) Electrochim. Acta, 146, pp. 106-111; Dai, T., Qing, X., Wang, J., Shen, C., Lu, Y., (2010) Compos. Sci. Technol., 70, pp. 498-503; Zhao, Y.X., Ren, K.F., Sun, Y.X., Li, Z.J., Ji, J., (2014) RSC Adv., 4, pp. 24511-24517; Słoniewska, A., Pałys, B., (2014) Electrochim. Acta, 126, pp. 90-97; Kwon, I.C., Bae, Y.H., Kim, S.W., Control, J., (1994) Release, 30, pp. 155-159; Sutani, K., Kaetsu, I., Uchida, K., (2001) Radiat. Phys. Chem., 61, pp. 49-54; Murdan, S., Control, J., (2003) Release, 92, pp. 1-17; Indermun, S., Choonara, Y.E., Kumar, P., Du Toit, L.C., Modi, G., Luttge, R., Pillay, V., (2014) Int. J. Pharm., 462, pp. 52-65; Derakhsheshpoor, R., Homayoonfal, M., Akbari, A., Reza, M.J., (2013) J. Environ. Health Sci. Eng., 11, p. 9; Jeon, G., Yang, S.Y., Byun, J., Kim, J.K., (2011) Nano Lett., 11, pp. 1284-1288; Ricka, J., Tanaka, T., (1984) Macromolecules, 17, pp. 2916-2921; Yang, Y., Engberts, J.B.F.N., (2000) Colloids Surf. A, 169, pp. 85-94; Takahashi, S.H., Lira, L.M., De Torresi, S.I.C., (2012) J. Biomater. Bionanotechnol., 3, pp. 262-268; Siepmann, J., Peppas, N.A., (2001) Adv. Drug Deliv. Rev., 48, pp. 139-157; Bus, J.S., Popp, J.A., (1987) Food Chem. Toxicol., 25, pp. 619-626; Dispenza, C., Sabatino, M.A., Niconov, A., Chmielewska, D., Spadaro, G., (2012) Radiat. Phys. Chem., 81, pp. 1456-1459; Mattioli, M., Giavaresi, G., Biagini, G., Virgili, L., Giacomini, M., Fini, M., Giantomassi, F., Giardino, R., (2003) Int. J. Artif. Organs, 26, pp. 1077-1085; Bidez, P.R., Li, S., MacDiarmid, A.G., Venancio, E.C., Wei, Y., Lelkes, P.I., (2006) J. Biomater. Sci. Polym. Ed., 17, pp. 199-212; Qazi, T.H., Rai, R., Boccaccini, A.R., (2014) Biomaterials, 35, pp. 9068-9086

PY - 2016/3/1

Y1 - 2016/3/1

N2 - © 2015 Elsevier B.V. All rights reserved. Polyacrylamide (PAAm) hydrogel containing nanofibers of polyaniline (PANI) has been prepared in order to evaluate it as electric stimuli-responsive material. Amoxicillin was loaded onto chemically synthesized PANI nanofibers of large-aspect-ratio. Composite hydrogel was obtained by the in situ incorporation of amoxicillin-loaded PANI during polymerization and reticulation of acrylamide. TEM images of cross sections of PAAm/amoxicillin-loaded PANI composite revealed a continuous 3D nanofiber network of PANI supported by the hydrogel matrix. The antibiotic molecules were accurately released (or sustained) from composite hydrogel in response to application (or removal) of cathodic electrical stimulation. In vitro cytotoxicity evaluation of composite hydrogel extract on mouse subcutaneous connective tissue has shown cell viability higher than 80%. The tuning release profile and minimal toxicity of the material evidenced its potential for electrically controlled drug delivery applications such as implantable devices and transdermal drug delivery systems.

AB - © 2015 Elsevier B.V. All rights reserved. Polyacrylamide (PAAm) hydrogel containing nanofibers of polyaniline (PANI) has been prepared in order to evaluate it as electric stimuli-responsive material. Amoxicillin was loaded onto chemically synthesized PANI nanofibers of large-aspect-ratio. Composite hydrogel was obtained by the in situ incorporation of amoxicillin-loaded PANI during polymerization and reticulation of acrylamide. TEM images of cross sections of PAAm/amoxicillin-loaded PANI composite revealed a continuous 3D nanofiber network of PANI supported by the hydrogel matrix. The antibiotic molecules were accurately released (or sustained) from composite hydrogel in response to application (or removal) of cathodic electrical stimulation. In vitro cytotoxicity evaluation of composite hydrogel extract on mouse subcutaneous connective tissue has shown cell viability higher than 80%. The tuning release profile and minimal toxicity of the material evidenced its potential for electrically controlled drug delivery applications such as implantable devices and transdermal drug delivery systems.

KW - Electrically controlled drug release

KW - Electroconductive hydrogels

KW - Electroconductive polymer

KW - Acrylic monomers

KW - Aspect ratio

KW - Collagen

KW - Conducting polymers

KW - Controlled drug delivery

KW - Drug products

KW - Electric conductivity

KW - Implants (surgical)

KW - Musculoskeletal system

KW - Nanofibers

KW - Polyaniline

KW - Composite hydrogels

KW - Controlled drug release

KW - Drug delivery applications

KW - Electrical stimulations

KW - Electroconductive

KW - Electroconductive polymers

KW - Nanocomposite hydrogels

KW - Transdermal drug delivery systems

KW - Hydrogels

UR - http://www.scopus.com/inward/record.url?scp=84953775417&partnerID=8YFLogxK

U2 - 10.1016/j.reactfunctpolym.2015.12.017

DO - 10.1016/j.reactfunctpolym.2015.12.017

M3 - Article

SN - 1381-5148

VL - 100

SP - 12

EP - 17

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

ER -

Electroconductive nanocomposite hydrogel for pulsatile drug release

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