Electrospray-assisted fabrication of core-shell arabinoxylan gel particles for insulin and probiotics entrapment

R. Paz-Samaniego, A. Rascón-Chu, F. Brown-Bojorquez, E. Carvajal-Millan, M. Pedroza-Montero, E. Silva-Campa, N. Sotelo-Cruz, Y.L. López-Franco, J. Lizardi-Mendoza

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29 Scopus citations


This work presents the fabrication and characterization of electro-sprayed core-shell particles that were composed of maize bran arabinoxylans (MBAX) with insulin in the core, and maize wastewater arabinoxylans (MWAX) with Bifidobacterium in the shell. Two concentrations of MBAX (3% and 6% w/v) and MWAX (6% and 10% w/v) were evaluated. The particles fabricated with MBAX at 6% (w/v) in the core and MWAX at 10% (w/v) in the shell were more stable, presented spherical shape and no aggregation being therefore selected to be loaded with insulin and probiotics. These particles presented a size of 2.9 mm. Scanning electron microscopy analysis of the particle cross section revealed the presence of both, a smooth (shell) and a porous (core) microstructure. Confocal laser scanning microscopy confirmed the core-shell structure of the particles and the viability of the probiotic entrapped. Gastrointestinal simulation strongly suggests that these particles are not degraded in the stomach and small intestine and that 76% of the carried insulin is released in colon. These results indicate that insulin and Bifidobacterium encapsulation by tetraaxial electro spraying can be a feasible and adequate technique to produce arabinoxylan capsules containing both insulin and probiotics.

Original languageEnglish
Article number46411
JournalJournal of Applied Polymer Science
Issue number26
StatePublished - 10 Jul 2018

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© 2018 Wiley Periodicals, Inc.


  • biodegradable
  • biomaterials
  • biopolymers and renewable polymers
  • polysaccharides
  • proteins


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