Electrospun tubes based on PLA, gelatin and genipin in different arrangements for blood vessel tissue engineering

Abraham Alejandro Leyva-Verduzco, María Mónica Castillo-Ortega*, Lerma Hanaiy Chan-Chan, Erika Silva-Campa, Ramsés Galaz-Méndez, Ricardo Vera-Graziano, José Carmelo Encinas-Encinas, Teresa Del Castillo-Castro, Dora Evelia Rodríguez-Félix, Hisila del Carmen Santacruz-Ortega, Irela Santos-Sauceda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Four tubular membranes based on PLA and gelatin with different arrangements (PLA, gelatin, PLA-gelatin Blend and PLA/gelatin Core/Shell) were prepared by the electrospinning technique, the gelatin within the materials was crosslinked with genipin and all the meshes were characterized by SEM, ATR-FTIR, TGA, DSC, XRD and mechanical tests, also a viability essay and a confocal microscopy of HUVECs in contact with the materials were carried out. A 50% decrement of cellular viability was observed in the fibers with Core/Shell structure since the first day of culture compared with the tissue culture polystyrene, due to solubilization of non-crosslinked gelatin.

Original languageEnglish
Pages (from-to)5985-6003
Number of pages19
JournalPolymer Bulletin
Volume77
Issue number11
DOIs
StateAccepted/In press - 2019

Bibliographical note

Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

  • Electrospinning
  • Gelatin
  • Poly(lactic acid)
  • Tissue engineering

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