ESBL-producing Escherichia coli and Klebsiella pneumoniae from health-care institutions in Mexico

Viridiana Gallegos-Miranda, Ulises Garza-Ramos, Enrique Bolado-Martínez*, Moisés Navarro-Navarro, Katya Rocío Félix-Murray, Maria del Carmen Candia-Plata, Guillermina Sanchez-Martinez, Josefina Dúran-Bedolla, Jesús Silva-Sánchez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We investigated the phenotypic and molecular characteristics of Extended-Spectrum-β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates from four health-care institutions in Hermosillo, Sonora, Mexico. ESBL-producing isolates were collected from February to August 2016. The prevalence of ESBL-producing E. coli and K. pneumoniae was 11.9 and 8.7%, respectively. High dissemination of resistance to ciprofloxacin (88%), trimethoprim/sulfamethoxazole (72%) and aminoglycosides (59%) were detected, as well as susceptibility to meropenem, amikacin and tigecycline. The ESBL found variants were CTX-M-1 (88%) and CTX-M-9 (5%). The plasmid-mediated quinolone resistance (PMQR) gene aac(6´)-Ib-cr was identified in 62% of a representative sample, whereas the qnrB and qnrS genes were detected in 49% of the isolates. PFGE analyses detected many unrelated clones among the hospital or community isolates. A constant programme of epidemiological surveillance is recommended to understand the dynamics of bacterial resistance to both cephalosporin as well as the fluoroquinolone family of antibiotics.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalJournal of Chemotherapy
Volume33
Issue number2
DOIs
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 Edizioni Scientifi che per l'Informazione su Farmaci e Terapia.

Keywords

  • PFGE
  • PMQR
  • aac(6´)-Ib-cr
  • qnrB
  • qnrS
  • quinolone resistance
  • β-lactamases

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