Factores predictores para la función retardada del injerto renal: estudio retrospectivo

Objective: To know the frequency and factors associated with delayed graft function (DGF) in a tertiary care center in northwestern Mexico. Methods: Retrospectively, transplanted patients from 2011 to 2017 and their association to DGF were reviewed. The DGF was defined as a case that required dialysis within the first post-transplant week. For the analysis of the variables involved in DGF, logistic regression was used. Results: Delayed graft function occurred in 11% (CI 95%, 7 to 15) of 199 transplants studied. The risk factors associated with DGF included: combined renal replacement therapy (OR: 3.50; CI 95%: 1.39 to 8.78; p=0.005), cadaveric donor (OR: 8.06; CI 95%: 1.82 to 35.53; p=0.001), cardiovascular disease (OR: 4.32; CI 95%: 0.74 to 25.12; p=0.07), and acute rejection (OR: 2.78; CI 95%: 0.98 to 7.90; p=0.04). The multiva- riate analysis demonstrated combined renal replacement therapy (OR: 3.34; p=0.01) and cadaveric donor (OR: 8.02; p=0.007) as independent risk factors for DGF (OR: 8.02; p=0.007).
Conclusions: The factors associated with DGF observed in the present study are related to the kidney recipient and the donor. Further prog- nostic studies that permit the discovery of the influence that diverse known factors have in the development of DGF and the prognosis for the transplanted organ are required.