TY - JOUR
T1 - Fiebre maculosa de las Montañas Rocosas en niños y adolescentes mexicanos
T2 - Cuadro clínico y factores de mortalidad
AU - Álvarez-Hernández, Gerardo
AU - del Carmen Candia-Plata, María
AU - Delgado-de la Mora, Jesús
AU - Acuña-Meléndrez, Natalia Haydeé
AU - Vargas-Ortega, Anabel Patricia
AU - Licona-Enríquez, Jesús David
PY - 2016
Y1 - 2016
N2 - Objective: Characterize clinical manifestations and predictors of mortality in children hospitalized for spotted fever. Materials and methods: Cross-sectional study in 210 subjects with a diagnosis of Rocky Mountain spotted fever (RMSF) in a pediatric hospital in Sonora, from January 1st, 2004 to June 30th, 2015. Data were analyzed using descriptive statistics and multivariate logistic regression. Results: An upward trend was observed in RMSF morbidity and mortality. Fatality rate was 30%. Three predictors were associated with risk of death: delay ≥ 5 days at the start of doxycycline (ORa = 2.95, 95% CI 1.10-7.95), acute renal failure ((ORa = 8.79, 95% CI 3.46-22.33) and severe sepsis (ORa = 3.71, 95% CI 1.44-9.58). Conclusions: RMSF causes high mortality in children, which can be avoided with timely initiation of doxycycline. Acute renal failure and severe sepsis are two independent predictors of death in children with RMSF.
AB - Objective: Characterize clinical manifestations and predictors of mortality in children hospitalized for spotted fever. Materials and methods: Cross-sectional study in 210 subjects with a diagnosis of Rocky Mountain spotted fever (RMSF) in a pediatric hospital in Sonora, from January 1st, 2004 to June 30th, 2015. Data were analyzed using descriptive statistics and multivariate logistic regression. Results: An upward trend was observed in RMSF morbidity and mortality. Fatality rate was 30%. Three predictors were associated with risk of death: delay ≥ 5 days at the start of doxycycline (ORa = 2.95, 95% CI 1.10-7.95), acute renal failure ((ORa = 8.79, 95% CI 3.46-22.33) and severe sepsis (ORa = 3.71, 95% CI 1.44-9.58). Conclusions: RMSF causes high mortality in children, which can be avoided with timely initiation of doxycycline. Acute renal failure and severe sepsis are two independent predictors of death in children with RMSF.
KW - Adolescents
KW - Children
KW - Mexico
KW - Rocky mountain spotted fever
UR - http://www.scopus.com/inward/record.url?scp=84969941410&partnerID=8YFLogxK
U2 - 10.21149/spm.v58i3.7908
DO - 10.21149/spm.v58i3.7908
M3 - Artículo
SN - 0036-3634
VL - 58
SP - 385
EP - 392
JO - Salud publica de Mexico
JF - Salud publica de Mexico
IS - 3
ER -