First Report of the Emerging Pathogen Kodamaea ohmeri in Honduras

Bryan Ortiz, Roque López, Carlos Muñoz, Kateryn Aguilar, Fernando Pérez, Isis Laínez-Arteaga, Fernando Chávez, Celeste Galindo, Luis Rivera, Manuel G. Ballesteros-Monrreal, Pablo Méndez-Pfeiffer, Dora Valencia, Gustavo Fontecha*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Kodamaea ohmeri is an environmental yeast considered a rare emerging pathogen. In clinical settings, the correct identification of this yeast is relevant because some isolates are associated with resistance to antifungals. There is a lack of available data regarding the geographical distribution, virulence, and drug resistance profile of K. ohmeri. To contribute to the knowledge of this yeast, this study aimed to describe in depth three isolates of K. ohmeri associated with fungemia in Honduras. The identification of the isolates was carried out by sequencing the ribosomal ITS region. In addition, the susceptibility profile to antifungals was determined, and some properties associated with virulence were evaluated (exoenzyme production, biofilm formation, cell adhesion, and invasion). The isolates showed strong protease, phospholipase, and hemolysin activity, in addition to being biofilm producers. Adherence and invasion capacity were evident in the HeLa and Raw 264.7 cell lines, respectively. This study expands the understanding of the underlying biological traits associated with virulence in K. ohmeri, and it is the first report of the detection and identification of K. ohmeri in Honduras as a cause of human infection.

Original languageEnglish
Article number186
JournalJournal of Fungi
Issue number3
StatePublished - Mar 2024

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  • Honduras
  • Kodamaea ohmeri
  • adhesion
  • diagnosis
  • macrophages
  • virulence


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