In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.
Bibliographical noteFunding Information:
This study was supported by PAPIIT-DGAPA-UNAM (PAPIIT IN210520) andCONACYTA1-S-33933.
The financial support of this research by PAPIIT-DGAPA-UNAM (PAPIIT IN210520) and CONACYT A1-S-33933 is gratefully acknowledged. E.R.F. would like to thank Programa de Becas Posdoctorales-DGAPA-UNAM for a postdoctoral scholarship (Ofi-cio: CJIC/CTIC/1139/2020).
© 2021 Bentham Science Publishers.
- Fluorinated complexes
- N-heterocyclic carbene (NHC)
- NHC complexes