Fluorinated-NHC transition metal complexes: Leading characters as potential anticancer metallodrugs

Ernesto Rufino-Felipe, Raúl Colorado-Peralta, Viviana Reyes-Márquez, Hugo Valdés, David Morales-Morales*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.

Original languageEnglish
Pages (from-to)938-948
Number of pages11
JournalAnti-Cancer Agents in Medicinal Chemistry
Issue number8
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 Bentham Science Publishers.


  • Cancer
  • Cytotoxicity
  • Fluorinated complexes
  • Fluorine
  • Metallodrugs
  • N-heterocyclic carbene (NHC)
  • NHC complexes


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