TY - JOUR
T1 - Herbicide biomonitoring in agricultural workers in Valle del Mayo, Sonora Mexico
AU - Balderrama-Carmona, Ana Paola
AU - Valenzuela-Rincón, Melissa
AU - Zamora-Álvarez, Luis Alberto
AU - Adan-Bante, Norma Patricia
AU - Leyva-Soto, Luis Alonso
AU - Silva-Beltrán, Norma Patricia
AU - Morán-Palacio, Edgar Felipe
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Valle del Mayo is an important agricultural area at the northwest of Mexico where up to 20,000 L of a mix composed of glyphosate and tordon is used in drains and canals. This study was carried out in order to evaluate the cellular damage caused by glyphosate, aminomethylphosphonic acid (AMPA), and picloram in agricultural workers. Biomonitoring was performed through the quantification of herbicides in urine using HPLC (high-performance liquid chromatography) to then evaluate the cellular damage in exposed people by means of an evaluation of micronuclei and cellular proliferation in lymphocyte cultures. The urine samples (n = 30) have shown a concentration of up to 10.25 μg/L of picloram and 2.23 μg/L of AMPA; no positive samples for glyphosate were reported. The calculation of the external dose reveals that agricultural workers ingest up to 146 mg/kg/day; however, this concentration does not surpass the limits that are allowed internationally. As for the results for the micronuclei test, 53% of the workers showed cellular damage, and the nuclear division index test reported that there was a significant difference (P < 0.05) between the exposed and the control population, which indicated that the exposure time to pesticides in the people of Valle del Mayo can induce alterations which can cause chronic damage.
AB - Valle del Mayo is an important agricultural area at the northwest of Mexico where up to 20,000 L of a mix composed of glyphosate and tordon is used in drains and canals. This study was carried out in order to evaluate the cellular damage caused by glyphosate, aminomethylphosphonic acid (AMPA), and picloram in agricultural workers. Biomonitoring was performed through the quantification of herbicides in urine using HPLC (high-performance liquid chromatography) to then evaluate the cellular damage in exposed people by means of an evaluation of micronuclei and cellular proliferation in lymphocyte cultures. The urine samples (n = 30) have shown a concentration of up to 10.25 μg/L of picloram and 2.23 μg/L of AMPA; no positive samples for glyphosate were reported. The calculation of the external dose reveals that agricultural workers ingest up to 146 mg/kg/day; however, this concentration does not surpass the limits that are allowed internationally. As for the results for the micronuclei test, 53% of the workers showed cellular damage, and the nuclear division index test reported that there was a significant difference (P < 0.05) between the exposed and the control population, which indicated that the exposure time to pesticides in the people of Valle del Mayo can induce alterations which can cause chronic damage.
KW - AMPA
KW - Cellular damage
KW - Glyphosate
KW - Herbicide pollution
KW - Occupational health
KW - Picloram
KW - Urine
UR - http://www.scopus.com/inward/record.url?scp=85076608813&partnerID=8YFLogxK
U2 - 10.1007/s11356-019-07087-6
DO - 10.1007/s11356-019-07087-6
M3 - Artículo
C2 - 31832947
AN - SCOPUS:85076608813
SN - 0944-1344
VL - 27
SP - 28480
EP - 28489
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
IS - 23
ER -