Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery

A. M. Morales-Burgos*, E. Carvajal-Millan, N. Sotelo-Cruz, A. Rascón-Chu, J. Lizardi-Mendoza, Y. L. López-Franco, Marcel Martínez-Porchas, R. Canett-Romero

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume163
DOIs
StatePublished - Jun 2021

Bibliographical note

Funding Information:
This work was supported by a grant from the Fondo Institucional CONACyT – Investigación en Fronteras de la Ciencia, Mexico (Grant FONT.INST./2015/487 to E. Carvajal-Millan). The authors are pleased to acknowledge Eduardo J. Galván-García (FCQB-UAS), José de Jesús Castro Cordova (Bioterio-UNISON) and Alma C. Campa Mada (CIAD) for technical assistance. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Funding Information:
This work was supported by a grant from the Fondo Institucional CONACyT – Investigación en Fronteras de la Ciencia, Mexico (Grant FONT.INST./2015/487 to E. Carvajal-Millan). The authors are pleased to acknowledge Eduardo J. Galván-García (FCQB-UAS), José de Jesús Castro Cordova (Bioterio-UNISON) and Alma C. Campa Mada (CIAD) for technical assistance.

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

  • Arabinoxylans
  • Colon-targeted
  • Drug-delivery
  • Insulin carrier
  • Microspheres

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