Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery

A. M. Morales-Burgos*, E. Carvajal-Millan, N. Sotelo-Cruz, A. Rascón-Chu, J. Lizardi-Mendoza, Y. L. López-Franco, Marcel Martínez-Porchas, R. Canett-Romero

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume163
DOIs
StatePublished - Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

  • Arabinoxylans
  • Colon-targeted
  • Drug-delivery
  • Insulin carrier
  • Microspheres

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