Hipoglucemia hiperinsulinémica persistente. Informe de dos casos.

Norberto Sotelo-Cruz; Andrés Cordero-Olivares; Carlos Ramírez-Rodríguez; Guillermo López-Cervantes; Jaime Hurtado-Valenzuela; Brenda María López-Cervantes

Hipoglucemia hiperinsulinémica persistente. Informe de dos casos.

Translated title of the contribution: Persistent hyperinsulinemic hypoglycemia. Two case reports

Norberto Sotelo-Cruz^*, Andrés Cordero-Olivares, Carlos Ramírez-Rodríguez, Guillermo López-Cervantes, Jaime Hurtado-Valenzuela, Brenda María López-Cervantes

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We report two cases of infants who presented seizures and persistent hypoglycemia. In both infants, we established diagnosis of persistent hypoglycemia by hyperinsulinism (PHH); glycemic/insulinic ratio was > 0.3, and we found no pancreatic changes by means of other diagnostic procedures. The medical treatment consisted of hydrocortisone, diazoxide, and octreotide without response. Definitive treatment made was sub-total pancreatectomy; postoperatory evolution was satisfactory, and the histologic report showed changes in Langerhans islet of nesidioblastosis. We conclude that PHH and glucose/insulin ratio > 0.3 indicates that surgical treatment with pancreatectomy should not be delayed.

Translated title of the contribution	Persistent hyperinsulinemic hypoglycemia. Two case reports
Original language	Spanish
Pages (from-to)	409-414
Number of pages	6
Journal	Cirugia y Cirujanos
Volume	72
Issue number	5
State	Published - 2004
Externally published	Yes

Cite this

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title = "Hipoglucemia hiperinsulin{\'e}mica persistente. Informe de dos casos.",

abstract = "We report two cases of infants who presented seizures and persistent hypoglycemia. In both infants, we established diagnosis of persistent hypoglycemia by hyperinsulinism (PHH); glycemic/insulinic ratio was > 0.3, and we found no pancreatic changes by means of other diagnostic procedures. The medical treatment consisted of hydrocortisone, diazoxide, and octreotide without response. Definitive treatment made was sub-total pancreatectomy; postoperatory evolution was satisfactory, and the histologic report showed changes in Langerhans islet of nesidioblastosis. We conclude that PHH and glucose/insulin ratio > 0.3 indicates that surgical treatment with pancreatectomy should not be delayed.",

author = "Norberto Sotelo-Cruz and Andr{\'e}s Cordero-Olivares and Carlos Ram{\'i}rez-Rodr{\'i}guez and Guillermo L{\'o}pez-Cervantes and Jaime Hurtado-Valenzuela and L{\'o}pez-Cervantes, {Brenda Mar{\'i}a}",

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language = "Espa{\~n}ol",

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pages = "409--414",

journal = "Cirugia y Cirujanos",

issn = "0009-7411",

publisher = "Mexican Academy of Surgery",

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TY - JOUR

T1 - Hipoglucemia hiperinsulinémica persistente. Informe de dos casos.

AU - Sotelo-Cruz, Norberto

AU - Cordero-Olivares, Andrés

AU - Ramírez-Rodríguez, Carlos

AU - López-Cervantes, Guillermo

AU - Hurtado-Valenzuela, Jaime

AU - López-Cervantes, Brenda María

PY - 2004

Y1 - 2004

N2 - We report two cases of infants who presented seizures and persistent hypoglycemia. In both infants, we established diagnosis of persistent hypoglycemia by hyperinsulinism (PHH); glycemic/insulinic ratio was > 0.3, and we found no pancreatic changes by means of other diagnostic procedures. The medical treatment consisted of hydrocortisone, diazoxide, and octreotide without response. Definitive treatment made was sub-total pancreatectomy; postoperatory evolution was satisfactory, and the histologic report showed changes in Langerhans islet of nesidioblastosis. We conclude that PHH and glucose/insulin ratio > 0.3 indicates that surgical treatment with pancreatectomy should not be delayed.

AB - We report two cases of infants who presented seizures and persistent hypoglycemia. In both infants, we established diagnosis of persistent hypoglycemia by hyperinsulinism (PHH); glycemic/insulinic ratio was > 0.3, and we found no pancreatic changes by means of other diagnostic procedures. The medical treatment consisted of hydrocortisone, diazoxide, and octreotide without response. Definitive treatment made was sub-total pancreatectomy; postoperatory evolution was satisfactory, and the histologic report showed changes in Langerhans islet of nesidioblastosis. We conclude that PHH and glucose/insulin ratio > 0.3 indicates that surgical treatment with pancreatectomy should not be delayed.

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M3 - Artículo

SN - 0009-7411

VL - 72

SP - 409

EP - 414

JO - Cirugia y Cirujanos

JF - Cirugia y Cirujanos

IS - 5

ER -

Hipoglucemia hiperinsulinémica persistente. Informe de dos casos.

Abstract

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