Abstract
The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a demonstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocolitis was found.
Original language | English |
---|---|
Pages (from-to) | 833-836 |
Number of pages | 4 |
Journal | Parasitology Research |
Volume | 85 |
Issue number | 10 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Bibliographical note
Funding Information:Acknowledgements The authors wish to thank Mrs. Isabel Pérez-Montfort for assistance in manuscript elaboration and Mrs. Ma. Elena Ortiz-Tadeo for secretarial help. This work was supported by National Council for Science and Technology (CONACYT) grant 3065M9306 and by National University of Mexico, UNAM (DGAPA), grant IN201695. The experiments comply with the current ethics laws of the country in which the experiments were performed.