In vitro antiviral effect of Mexican and Brazilian propolis and phenolic compounds against human coronavirus 229E

Norma Patricia Silva-Beltrán*, Juan Carlos Galvéz-Ruíz, Luisa A. Ikner, Marcelo Andrés Umsza-Guez, Thiago Luiz de Paula Castro, Charles P. Gerba

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Propolis is a resinous substance collected by bees (Apis mellifera). It is used for its biological properties. This natural product is available as a safe therapeutic option. Herein, we report the antiviral effects of brown propolis extract from Mexico and green and red propolis extracts from Brazil, as well as their phenolic compounds (quercetin, caffeic acid, and rutin) in preventing infection of MRC-5 cells by HCoV-229E. Normal human fibroblast lung cells (MRC-5) were used to determine the cytotoxicity of the compounds. All samples studied showed antiviral activity. Green and brown propolis extracts, and quercetin exhibited the best EC50 values with values of 19.080, 11.240, and 77.208 µg/mL against HCoV-229E, respectively, and with TC50 of 62.19, 29.192, and 298 µg/mL on MRC-5 cells, respectively. These results are the first in vitro study of the effects of propolis on HCoV-229E and provide the basis for the development of natural formulations against other coronavirus strains.

Original languageEnglish
JournalInternational Journal of Environmental Health Research
DOIs
StateAccepted/In press - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • caffeic acid
  • coronavirus
  • propolis
  • quercetin
  • rutin

Fingerprint

Dive into the research topics of 'In vitro antiviral effect of Mexican and Brazilian propolis and phenolic compounds against human coronavirus 229E'. Together they form a unique fingerprint.

Cite this