Increased serum ferritin is associated with oxidized low-density lipoprotein in prediabetes patients: A pilot study

Juan Manuel Martínez-Soto, Maria del Carmen Candia-Plata, Luis Fernando López-Soto, Jesus Adriana Soto Guzman, Alma Yolanda Camacho-Villa, Gerardo Álvarez-Hernández, Ana Lourdes Mata-Pineda, José Manuel Galván-Moroyoqui*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Aims: This pilot study aimed to determine if increased serum ferritin (SF) is associated with cardiovascular risk factors in patients with prediabetes. Methods: Eighteen patients with prediabetes and 36 subjects without prediabetes (control), non-white Hispanic, non-indigenous origin, Mexican mestizo descent were included. Participants had no inflammation, or vascular complications. SF and metabolic markers were evaluated in both groups. Results: SF and oxidized low-density lipoprotein (oxLDL) were increased in prediabetes subjects. Moreover, in prediabetes and control groups as a whole, natural logarithm (ln)-SF correlated with oxLDL and ln-oxLDL/LDL after adjustment for sex, ln-age, ln-fasting plasma glucose (FPG), ln-body mass index, ln-triglyceride (TG), total cholesterol (TC), and high-density lipoproteins. Finally, ln-SF was an independent contributor to ln-oxLDL/LDL ratio in control and prediabetes subjects (β = 0.2915) after the introduction of potential confounders such as FPG, TC, TG, and hypertension. Conclusions: The results of this study indicate that hyperferritinemia is associated with oxLDL, considered one of the main cardiovascular risk factors, which allows us to suggest that an increase in SF could contribute to the progression of prediabetes, prior to the appearance of diabetes. Further research is required to establish a causal relationship of iron disruption metabolism in oxLDL generation under prediabetes conditions.

Original languageEnglish
Article numbere06720
Issue number4
StatePublished - Apr 2021

Bibliographical note

Funding Information:
MS-JM was a predoctoral fellow of the Consejo Nacional de Ciencia y Tecnolog?a (Mexico) during the conduct of this research. The realization of this work required an interinstitutional effort. The authors are grateful to all those who made it possible.

Publisher Copyright:
© 2021 The Author(s)


  • Atherosclerosis
  • Impaired fasting glucose
  • Oxidized low-density lipoprotein
  • Prediabetes
  • Serum ferritin


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