Iron Carbide@Iron Oxide Core-Shell Nanoparticles Functionalization with L-Arginine Amphiphillic Bioconjugate

Paul Zavala Rivera, Jesús Armando Lucero Acuña, Patricia Guerrero Germán, Aaron de Jesús Rosas Durazo, Lizbeth Alcantara Bastida, Anya Isabel Argüelles Pesqueira*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Metallic nanoparticles perform as therapeutic agents because of their precise response to optical, electrical, magnetic, physicochemical fields, and other stimulation processes at the nanometric scale. Targeted drug delivery using nanoparticles has been one of the most researched fields in recent years to improve the degree of precision, decrease treatment times, and reduce side effects compared to existing conventional methods. Nowadays, one nanoparticle synthesis and encapsulation process is improving green chemistry with surfactants conducive to increasing the biodegradability and biocompatibility of metal nanoparticles. Amino acid surfactants can provide functional groups with high affinity to the application site in drug delivery applications and reduce toxicity originating from the characteristic aggregation of metal nanoparticles. In that regard, functionalization by amino acids increases the use of metal nanoparticles. Arginine, as a surfactant in the nanometric scale and, at low concentrations, is used in cancer therapy, hormone deliberation, and drug delivery in biological systems. In this work, we evaluate polypeptides potentially used in various applications with metallic nanoparticles, such as separator agents in biological environments. Herein, oleic acid (OA) was bioconjugated with L-Arginine (OAR) to change iron carbide@ iron oxide nanoparticles (ICIONPs) core-shell type from hydrophobic to hydrophilic. The synthesis route is based on bioconjugation techniques, using N'N-Dicyclohexilcarbodimiide by nucleophilic substitution of the carboxyl group performed at low temperatures. This study shows OAR nanoparticles size 55 ± 24 nm of oleic acid.

Original languageEnglish
Title of host publication45th Mexican Conference on Biomedical Engineering - Proceedings of CNIB 2022
EditorsCitlalli Jessica Trujillo-Romero, Rafael Gonzalez-Landaeta, Christian Chapa-González, Guadalupe Dorantes-Méndez, Dora-Luz Flores, J.J.Agustin Flores Cuautle, Martha R. Ortiz-Posadas, Ricardo A. Salido Ruiz, Esmeralda Zuñiga-Aguilar
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages10
ISBN (Print)9783031182556
StatePublished - 2023
Event45th Mexican Conference on Biomedical Engineering, CNIB 2022 - Puerto Vallarta, Mexico
Duration: 6 Oct 20228 Oct 2022

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277


Conference45th Mexican Conference on Biomedical Engineering, CNIB 2022
CityPuerto Vallarta

Bibliographical note

Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.


  • Arginine
  • Iron nanoparticles
  • Surfactant


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