Low number of peripheral blood B lymphocytes in patients with pulmonary tuberculosis

Jesús Hernandez; Carlos Velazquez; Olivia Valenzuela; Ramón Robles-Zepeda; Eduardo Ruiz-Bustos; Moisés Navarro; Adriana Garibay-Escobar

doi:10.3109/08820130903586346

Low number of peripheral blood B lymphocytes in patients with pulmonary tuberculosis

Jesús Hernandez, Carlos Velazquez, Olivia Valenzuela, Ramón Robles-Zepeda, Eduardo Ruiz-Bustos, Moisés Navarro, Adriana Garibay-Escobar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The cellular immune response plays a critical role in the containment of persistent Mycobacterium tuberculosis infection; however, the immunological mechanisms that lead to its control are not completely identified. The goal of this study was to evaluate B (CD19+) and T (CD3+) peripheral blood lymphocyte profiles and T-cell subsets (CD4+ and CD8+) in patients with pulmonary tuberculosis (TB). Percentages (p = 0.02) and absolute numbers (p = 0.005) of B cells were significantly lower in patients with pulmonary TB than in healthy donors. In contrast, percentages (p = 0.12) and absolute numbers (p = 0.14) of T cells were similar in TB patients and healthy donors. No significant differences in percentages of CD4+ (p = 0.19) or CD8+ (p = 0.85) T cells between patients and healthy donors were observed. In summary, patients with pulmonary tuberculosis had a lower number of peripheral blood B lymphocytes than healthy controls.

Original language	English
Pages (from-to)	197-205
Number of pages	9
Journal	Immunological Investigations
Volume	39
Issue number	3
DOIs	https://doi.org/10.3109/08820130903586346
State	Published - 2010

Bibliographical note

Funding Information:
This work was supported by Universidad de Sonora. The authors thank “Lab-oratorio Ramos” for the use of their flow cytometry unit.

Keywords

B lymphocytes
T lymphocytes
Tuberculosis

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10.3109/08820130903586346

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title = "Low number of peripheral blood B lymphocytes in patients with pulmonary tuberculosis",

abstract = "The cellular immune response plays a critical role in the containment of persistent Mycobacterium tuberculosis infection; however, the immunological mechanisms that lead to its control are not completely identified. The goal of this study was to evaluate B (CD19+) and T (CD3+) peripheral blood lymphocyte profiles and T-cell subsets (CD4+ and CD8+) in patients with pulmonary tuberculosis (TB). Percentages (p = 0.02) and absolute numbers (p = 0.005) of B cells were significantly lower in patients with pulmonary TB than in healthy donors. In contrast, percentages (p = 0.12) and absolute numbers (p = 0.14) of T cells were similar in TB patients and healthy donors. No significant differences in percentages of CD4+ (p = 0.19) or CD8+ (p = 0.85) T cells between patients and healthy donors were observed. In summary, patients with pulmonary tuberculosis had a lower number of peripheral blood B lymphocytes than healthy controls.",

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note = "Funding Information: This work was supported by Universidad de Sonora. The authors thank “Lab-oratorio Ramos” for the use of their flow cytometry unit.",

year = "2010",

doi = "10.3109/08820130903586346",

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AU - Hernandez, Jesús

AU - Velazquez, Carlos

AU - Valenzuela, Olivia

AU - Robles-Zepeda, Ramón

AU - Ruiz-Bustos, Eduardo

AU - Navarro, Moisés

AU - Garibay-Escobar, Adriana

N1 - Funding Information: This work was supported by Universidad de Sonora. The authors thank “Lab-oratorio Ramos” for the use of their flow cytometry unit.

PY - 2010

Y1 - 2010

N2 - The cellular immune response plays a critical role in the containment of persistent Mycobacterium tuberculosis infection; however, the immunological mechanisms that lead to its control are not completely identified. The goal of this study was to evaluate B (CD19+) and T (CD3+) peripheral blood lymphocyte profiles and T-cell subsets (CD4+ and CD8+) in patients with pulmonary tuberculosis (TB). Percentages (p = 0.02) and absolute numbers (p = 0.005) of B cells were significantly lower in patients with pulmonary TB than in healthy donors. In contrast, percentages (p = 0.12) and absolute numbers (p = 0.14) of T cells were similar in TB patients and healthy donors. No significant differences in percentages of CD4+ (p = 0.19) or CD8+ (p = 0.85) T cells between patients and healthy donors were observed. In summary, patients with pulmonary tuberculosis had a lower number of peripheral blood B lymphocytes than healthy controls.

AB - The cellular immune response plays a critical role in the containment of persistent Mycobacterium tuberculosis infection; however, the immunological mechanisms that lead to its control are not completely identified. The goal of this study was to evaluate B (CD19+) and T (CD3+) peripheral blood lymphocyte profiles and T-cell subsets (CD4+ and CD8+) in patients with pulmonary tuberculosis (TB). Percentages (p = 0.02) and absolute numbers (p = 0.005) of B cells were significantly lower in patients with pulmonary TB than in healthy donors. In contrast, percentages (p = 0.12) and absolute numbers (p = 0.14) of T cells were similar in TB patients and healthy donors. No significant differences in percentages of CD4+ (p = 0.19) or CD8+ (p = 0.85) T cells between patients and healthy donors were observed. In summary, patients with pulmonary tuberculosis had a lower number of peripheral blood B lymphocytes than healthy controls.

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KW - Tuberculosis

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JF - Immunological Investigations

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ER -

Low number of peripheral blood B lymphocytes in patients with pulmonary tuberculosis

Abstract

Bibliographical note

Keywords

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