Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

A. Angulo-Molina; M. A. Méndez-Rojas; T. Palacios-Hernández; O. E. Contreras-López; G. A. Hirata-Flores; J. C. Flores; K. L. Flores; C. Velázquez; R. Robles-Zepeda; E. Silva-Campa; A. Sarabia; M. Barboza-Flores; M. Pedroza-Montero; J. R. Reyes-Leyva; J. Hernández

doi:10.1016/j.matpr.2016.01.116

Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

A. Angulo-Molina, M. A. Méndez-Rojas, T. Palacios-Hernández, O. E. Contreras-López, G. A. Hirata-Flores, J. C. Flores, K. L. Flores, C. Velázquez, R. Robles-Zepeda, E. Silva-Campa, A. Sarabia, M. Barboza-Flores, M. Pedroza-Montero, J. R. Reyes-Leyva, J. Hernández

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Abstract

© 2016 Elsevier Ltd. Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.

Original language	American English
Pages	703-707
Number of pages	5
DOIs	https://doi.org/10.1016/j.matpr.2016.01.116
State	Published - 1 Jan 2016
Event	Materials Today: Proceedings - Duration: 1 Jan 2016 → …

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Conference	Materials Today: Proceedings
Period	1/01/16 → …

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Angulo-Molina, A., Méndez-Rojas, M. A., Palacios-Hernández, T., Contreras-López, O. E., Hirata-Flores, G. A., Flores, J. C., Flores, K. L., Velázquez, C., Robles-Zepeda, R., Silva-Campa, E., Sarabia, A., Barboza-Flores, M., Pedroza-Montero, M., Reyes-Leyva, J. R., & Hernández, J. (2016). Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects. 703-707. Paper presented at Materials Today: Proceedings. https://doi.org/10.1016/j.matpr.2016.01.116

Angulo-Molina, A. ; Méndez-Rojas, M. A. ; Palacios-Hernández, T. ; Contreras-López, O. E. ; Hirata-Flores, G. A. ; Flores, J. C. ; Flores, K. L. ; Velázquez, C. ; Robles-Zepeda, R. ; Silva-Campa, E. ; Sarabia, A. ; Barboza-Flores, M. ; Pedroza-Montero, M. ; Reyes-Leyva, J. R. ; Hernández, J. / Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects. Paper presented at Materials Today: Proceedings.5 p.

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title = "Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects",

abstract = "{\textcopyright} 2016 Elsevier Ltd. Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.",

author = "A. Angulo-Molina and M{\'e}ndez-Rojas, {M. A.} and T. Palacios-Hern{\'a}ndez and Contreras-L{\'o}pez, {O. E.} and Hirata-Flores, {G. A.} and Flores, {J. C.} and Flores, {K. L.} and C. Vel{\'a}zquez and R. Robles-Zepeda and E. Silva-Campa and A. Sarabia and M. Barboza-Flores and M. Pedroza-Montero and Reyes-Leyva, {J. R.} and J. Hern{\'a}ndez",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.matpr.2016.01.116",

language = "American English",

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Angulo-Molina, A, Méndez-Rojas, MA, Palacios-Hernández, T, Contreras-López, OE, Hirata-Flores, GA, Flores, JC, Flores, KL, Velázquez, C , Robles-Zepeda, R , Silva-Campa, E, Sarabia, A, Barboza-Flores, M , Pedroza-Montero, M, Reyes-Leyva, JR & Hernández, J 2016, 'Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects', Paper presented at Materials Today: Proceedings, 1/01/16 pp. 703-707. https://doi.org/10.1016/j.matpr.2016.01.116

Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects. / Angulo-Molina, A.; Méndez-Rojas, M. A.; Palacios-Hernández, T.; Contreras-López, O. E.; Hirata-Flores, G. A.; Flores, J. C.; Flores, K. L.; Velázquez, C.; Robles-Zepeda, R.; Silva-Campa, E.; Sarabia, A.; Barboza-Flores, M.; Pedroza-Montero, M.; Reyes-Leyva, J. R.; Hernández, J.

2016. 703-707 Paper presented at Materials Today: Proceedings.

Research output: Contribution to conference › Paper

TY - CONF

T1 - Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

AU - Angulo-Molina, A.

AU - Méndez-Rojas, M. A.

AU - Palacios-Hernández, T.

AU - Contreras-López, O. E.

AU - Hirata-Flores, G. A.

AU - Flores, J. C.

AU - Flores, K. L.

AU - Velázquez, C.

AU - Robles-Zepeda, R.

AU - Silva-Campa, E.

AU - Sarabia, A.

AU - Barboza-Flores, M.

AU - Pedroza-Montero, M.

AU - Reyes-Leyva, J. R.

AU - Hernández, J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - © 2016 Elsevier Ltd. Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.

AB - © 2016 Elsevier Ltd. Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.

U2 - 10.1016/j.matpr.2016.01.116

DO - 10.1016/j.matpr.2016.01.116

M3 - Paper

SP - 703

EP - 707

T2 - Materials Today: Proceedings

Y2 - 1 January 2016

ER -

Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

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