Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

A. Angulo-Molina; M. A. Méndez-Rojas; T. Palacios-Hernández; O. E. Contreras-López; G. A. Hirata-Flores; J. C. Flores; K. L. Flores; C. Velázquez; R. Robles-Zepeda; E. Silva-Campa; A. Sarabia; M. Barboza-Flores; M. Pedroza-Montero; J. R. Reyes-Leyva; J. Hernández

doi:10.1016/j.matpr.2016.01.116

Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

A. Angulo-Molina, M. A. Méndez-Rojas, T. Palacios-Hernández, O. E. Contreras-López, G. A. Hirata-Flores, J. C. Flores, K. L. Flores, C. Velázquez, R. Robles-Zepeda, E. Silva-Campa, A. Sarabia, M. Barboza-Flores, M. Pedroza-Montero^*, J. R. Reyes-Leyva, J. Hernández

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.

Original language	English
Pages (from-to)	703-707
Number of pages	5
Journal	Materials Today: Proceedings
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.matpr.2016.01.116
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd.

Keywords

Cancer
Magnetite nanoparticles
Vitamin E analogue
α-tocopheril succinate

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Angulo-Molina, A., Méndez-Rojas, M. A., Palacios-Hernández, T., Contreras-López, O. E., Hirata-Flores, G. A., Flores, J. C., Flores, K. L., Velázquez, C., Robles-Zepeda, R., Silva-Campa, E., Sarabia, A., Barboza-Flores, M., Pedroza-Montero, M., Reyes-Leyva, J. R., & Hernández, J. (2016). Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects. Materials Today: Proceedings, 3(2), 703-707. https://doi.org/10.1016/j.matpr.2016.01.116

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title = "Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects",

abstract = "Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.",

keywords = "Cancer, Magnetite nanoparticles, Vitamin E analogue, α-tocopheril succinate",

author = "A. Angulo-Molina and M{\'e}ndez-Rojas, {M. A.} and T. Palacios-Hern{\'a}ndez and Contreras-L{\'o}pez, {O. E.} and Hirata-Flores, {G. A.} and Flores, {J. C.} and Flores, {K. L.} and C. Vel{\'a}zquez and R. Robles-Zepeda and E. Silva-Campa and A. Sarabia and M. Barboza-Flores and M. Pedroza-Montero and Reyes-Leyva, {J. R.} and J. Hern{\'a}ndez",

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year = "2016",

doi = "10.1016/j.matpr.2016.01.116",

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Angulo-Molina, A, Méndez-Rojas, MA, Palacios-Hernández, T, Contreras-López, OE, Hirata-Flores, GA, Flores, JC, Flores, KL, Velázquez, C , Robles-Zepeda, R , Silva-Campa, E, Sarabia, A, Barboza-Flores, M , Pedroza-Montero, M, Reyes-Leyva, JR & Hernández, J 2016, 'Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects', Materials Today: Proceedings, vol. 3, no. 2, pp. 703-707. https://doi.org/10.1016/j.matpr.2016.01.116

TY - JOUR

T1 - Magnetite Nanoparticles Functionalized with Vitamin E Analogues

T2 - Anticancer Effects

AU - Angulo-Molina, A.

AU - Méndez-Rojas, M. A.

AU - Palacios-Hernández, T.

AU - Contreras-López, O. E.

AU - Hirata-Flores, G. A.

AU - Flores, J. C.

AU - Flores, K. L.

AU - Velázquez, C.

AU - Robles-Zepeda, R.

AU - Silva-Campa, E.

AU - Sarabia, A.

AU - Barboza-Flores, M.

AU - Pedroza-Montero, M.

AU - Reyes-Leyva, J. R.

AU - Hernández, J.

PY - 2016

Y1 - 2016

N2 - Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.

AB - Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.

KW - Cancer

KW - Magnetite nanoparticles

KW - Vitamin E analogue

KW - α-tocopheril succinate

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U2 - 10.1016/j.matpr.2016.01.116

DO - 10.1016/j.matpr.2016.01.116

M3 - Artículo

AN - SCOPUS:84963537253

SN - 2214-7853

VL - 3

SP - 703

EP - 707

JO - Materials Today: Proceedings

JF - Materials Today: Proceedings

IS - 2

ER -

Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

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Keywords

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