Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

A. Angulo-Molina, M. A. Méndez-Rojas, T. Palacios-Hernández, O. E. Contreras-López, G. A. Hirata-Flores, J. C. Flores, K. L. Flores, C. Velázquez, R. Robles-Zepeda, E. Silva-Campa, A. Sarabia, M. Barboza-Flores, M. Pedroza-Montero*, J. R. Reyes-Leyva, J. Hernández

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.

Original languageEnglish
Pages (from-to)703-707
Number of pages5
JournalMaterials Today: Proceedings
Issue number2
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd.


  • Cancer
  • Magnetite nanoparticles
  • Vitamin E analogue
  • α-tocopheril succinate


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