The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic ro-dents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase) activity. The polyphenolic MPE (138 mg EAG.g−1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH• 34 mgTE·g−1 ) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg·kg−1 ), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA-β) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration–response in vitro enzyme inhibitory activity (IC50 ≈ 0.085 mg·mL−1 ). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.
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Acknowledgments: A.M.P.-S. wish to thank the National Council of Science and Technology (CONACYT-Mexico) for the postgraduate scholarship received.
Funding: This research was partially supported by CONACYT, through Project “De los subproductos alimenticios de vegetales a nuevos productos de valor agregado, el papel de la tecnología en la bioeconomía” (funding number: 320351) and by Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD).
This research was partially supported by CONACYT, through Project ?De los subproductos alimenticios de vegetales a nuevos productos de valor agregado, el papel de la tecnolog?a en la bioeconom?a? (funding number: 320351) and by Centro de Investigaci?n en Alimentaci?n y Desarrollo A.C. (CIAD).
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- anti-diabetic effects
- mango peel
- phenolic compounds