Nanocomposite hydrogels of gellan gum and polypyrrole for electro-stimulated ibuprofen release application

Brianda María Salazar Salas, Genesis Adilene Grijalva Bustamante, Daniel Fernández Quiroz, María Mónica Castillo Ortega, José Carmelo Encinas, Pedro Jesús Herrera Franco, Teresa del Castillo Castro*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The development of stimuli-responsive release systems as functional platforms for controlled drug delivery is a valuable contribution to modern-day medical practice. In this work, novel electroactive nanocomposite hydrogels were prepared by encapsulating green-synthesized polypyrrole (PPy) colloids within bioamine-crosslinked gellan gum (GG) networks. The structural, physicochemical, and morphological properties of GG/PPy hydrogels were studied by Fourier transform infrared spectroscopy, thermogravimetry, rheological analysis, scanning electron microscopy, and swelling kinetic measurements. The hydrogels exhibited an interconnected porous structure with undefined boundaries. Viscoelastic properties and swelling behavior of materials were dependent on their filler content. In vitro ibuprofen (IBP) release studies from hydrogels were carried out without and under different electrical stimulations. The IBP release kinetic from GG/PPy hydrogels was remarkably activated by electrical stimuli. A unique pulse potential of 5 V increased the drug delivery up to 63% from nanocomposite hydrogel, in contrast to the low IBP amount released in a passive form (10%). The PPy reduction played a determining role as the main driving force in drug release activation. The tuning release profiles evidenced the potential of materials for electrically controlled drug delivery in implantable or transdermal drug release devices.

Original languageEnglish
Article number105296
JournalReactive and Functional Polymers
Volume176
DOIs
StatePublished - Jul 2022

Bibliographical note

Funding Information:
This research was funded by the Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico, grant number A1-S-26204, Ciencia Básica 2017–2018. B.M. Salazar Salas and G.A. Grijalva-Bustamante acknowledge CONACyT for their scholarships during this study. The authors thank Alan Germán Acedo Mendoza from the Nanomaterials Laboratory of the UNISON for the rheological measurements, and Irela Santos Sauceda for the thermal analysis.

Funding Information:
This research was funded by the Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico , grant number A1-S-26204 , Ciencia Básica 2017–2018. B.M. Salazar Salas and G.A. Grijalva-Bustamante acknowledge CONACyT for their scholarships during this study. The authors thank Alan Germán Acedo Mendoza from the Nanomaterials Laboratory of the UNISON for the rheological measurements, and Irela Santos Sauceda for the thermal analysis.

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

  • Electrically controlled drug release
  • Electroactive hydrogels
  • Gellan gum
  • Green chemistry
  • Polypyrrole

Fingerprint

Dive into the research topics of 'Nanocomposite hydrogels of gellan gum and polypyrrole for electro-stimulated ibuprofen release application'. Together they form a unique fingerprint.

Cite this