TY - JOUR
T1 - Nanoscale dose deposition in cell structures under X-ray irradiation treatment assisted with nanoparticles
T2 - An analytical approach to the relative biological effectiveness
AU - Melo-Bernal, W.
AU - Chernov, V.
AU - Chernov, G.
AU - Barboza-Flores, M.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/8
Y1 - 2018/8
N2 - In this study, an analytical model for the assessment of the modification of cell culture survival under ionizing radiation assisted with nanoparticles (NPs) is presented. The model starts from the radial dose deposition around a single NP, which is used to describe the dose deposition in a cell structure with embedded NPs and, in turn, to evaluate the number of lesions formed by ionizing radiation. The model is applied to the calculation of relative biological effectiveness values for cells exposed to 0.5 mg/g of uniformly dispersed NPs with a radius of 10 nm made of Fe, I, Gd, Hf, Pt and Au and irradiated with X-rays of energies 20 keV higher than the element K-shell binding energy.
AB - In this study, an analytical model for the assessment of the modification of cell culture survival under ionizing radiation assisted with nanoparticles (NPs) is presented. The model starts from the radial dose deposition around a single NP, which is used to describe the dose deposition in a cell structure with embedded NPs and, in turn, to evaluate the number of lesions formed by ionizing radiation. The model is applied to the calculation of relative biological effectiveness values for cells exposed to 0.5 mg/g of uniformly dispersed NPs with a radius of 10 nm made of Fe, I, Gd, Hf, Pt and Au and irradiated with X-rays of energies 20 keV higher than the element K-shell binding energy.
UR - http://www.scopus.com/inward/record.url?scp=85020737298&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2017.05.020
DO - 10.1016/j.apradiso.2017.05.020
M3 - Artículo
C2 - 28624366
SN - 0969-8043
VL - 138
SP - 50
EP - 55
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
ER -